There is an increasing interest in detecting genes, or genomic regions, that have been targeted by natural selection. The interest stems from a basic desire to learn more about evolutionary processes in humans and other organisms, and from the realization that inferences regarding selection may provide important functional information. This review provides a nonmathematical description of the issues involved in detecting selection from DNA sequences and SNP data and is intended for readers who are not familiar with population genetic theory. Particular attention is placed on issues relating to the analysis of large-scale genomic data sets.
Description
Molecular signatures of natural selection. [Annu Rev Genet. 2005] - PubMed result
%0 Journal Article
%1 nielsen2005review
%A Nielsen, R
%D 2005
%J Annu Rev Genet
%K review test_of_selection
%P 197-218
%R 10.1146/annurev.genet.39.073003.112420
%T Molecular signatures of natural selection
%U http://www.ncbi.nlm.nih.gov/pubmed/16285858
%V 39
%X There is an increasing interest in detecting genes, or genomic regions, that have been targeted by natural selection. The interest stems from a basic desire to learn more about evolutionary processes in humans and other organisms, and from the realization that inferences regarding selection may provide important functional information. This review provides a nonmathematical description of the issues involved in detecting selection from DNA sequences and SNP data and is intended for readers who are not familiar with population genetic theory. Particular attention is placed on issues relating to the analysis of large-scale genomic data sets.
@article{nielsen2005review,
abstract = {There is an increasing interest in detecting genes, or genomic regions, that have been targeted by natural selection. The interest stems from a basic desire to learn more about evolutionary processes in humans and other organisms, and from the realization that inferences regarding selection may provide important functional information. This review provides a nonmathematical description of the issues involved in detecting selection from DNA sequences and SNP data and is intended for readers who are not familiar with population genetic theory. Particular attention is placed on issues relating to the analysis of large-scale genomic data sets.},
added-at = {2010-03-29T00:08:04.000+0200},
author = {Nielsen, R},
biburl = {https://www.bibsonomy.org/bibtex/2472ec34b931de3bb07869ae1aa48b821/peter.ralph},
description = {Molecular signatures of natural selection. [Annu Rev Genet. 2005] - PubMed result},
doi = {10.1146/annurev.genet.39.073003.112420},
interhash = {bd4b4ce15cca2605656c57de342f050b},
intrahash = {472ec34b931de3bb07869ae1aa48b821},
journal = {Annu Rev Genet},
keywords = {review test_of_selection},
pages = {197-218},
pmid = {16285858},
timestamp = {2010-03-29T00:08:04.000+0200},
title = {Molecular signatures of natural selection},
url = {http://www.ncbi.nlm.nih.gov/pubmed/16285858},
volume = 39,
year = 2005
}