Colonization by Streptococcus pneumoniae among human immunodeficiency virus-infected adults: prevalence of antibiotic resistance, impact of immunization, and characterization by polymerase chain reaction with BOX primers of isolates from persistent S. pneumoniae carriers
Pharyngeal colonization by Streptococcus pneumoniae was evaluated in 103 human immunodeficiency virus (HIV)-infected subjects (\textless200 CD4 cells/microL, 57; \textgreater or = 200 CD4 cells/microL, 46) and 39 non-HIV-infected controls who were participants in a vaccine study. At baseline, 7\%, 20\%, and 10\% of subjects in the \textless200 and \textgreater or = 200 CD4 cell groups and in the control group were colonized with S. pneumoniae: Rates at 6 months were 23\%, 22\%, and 0\%, respectively. Of 34 isolates from HIV-infected subjects, 25 were penicillin-resistant and 19 were resistant to \textgreater or = 3 antimicrobials; of 8 isolates from controls, 1 was resistant. Resistance to trimethoprim-sulfamethoxazole was significantly higher among HIV-infected subjects with \textless200 CD4 cells/microL than in those with more CD4 cells. Polymerase chain reaction DNA analysis with BOX primers demonstrated that 12 HIV-infected subjects were persistently colonized with the same S. pneumoniae strain for \textgreater or = 1 month compared with none of the controls. HIV-infected subjects were more likely to be persistent pneumococcal carriers and to carry antibiotic-resistant isolates than were non-HIV-infected subjects.
%0 Journal Article
%1 rodriguez-barradas_colonization_1997
%A Rodriguez-Barradas, M C
%A Tharapel, R A
%A Groover, J E
%A Giron, K P
%A Lacke, C E
%A Houston, E D
%A Hamill, R J
%A Steinhoff, M C
%A Musher, D M
%D 1997
%J The Journal of Infectious Diseases
%K Adult, Aged, Bacterial, Carrier Chain Count, Drug Factors, Humans, Infections, Lymphocyte Male, Microbial, Middle Pharyngitis, Pharynx, Polymerase Reaction, Resistance, Risk State, Streptococcal Streptococcus pneumoniae {CD4} {DNA,} {HIV}
%N 3
%P 590--7
%T Colonization by Streptococcus pneumoniae among human immunodeficiency virus-infected adults: prevalence of antibiotic resistance, impact of immunization, and characterization by polymerase chain reaction with BOX primers of isolates from persistent S. pneumoniae carriers
%U http://www.ncbi.nlm.nih.gov/pubmed/9041330
%V 175
%X Pharyngeal colonization by Streptococcus pneumoniae was evaluated in 103 human immunodeficiency virus (HIV)-infected subjects (\textless200 CD4 cells/microL, 57; \textgreater or = 200 CD4 cells/microL, 46) and 39 non-HIV-infected controls who were participants in a vaccine study. At baseline, 7\%, 20\%, and 10\% of subjects in the \textless200 and \textgreater or = 200 CD4 cell groups and in the control group were colonized with S. pneumoniae: Rates at 6 months were 23\%, 22\%, and 0\%, respectively. Of 34 isolates from HIV-infected subjects, 25 were penicillin-resistant and 19 were resistant to \textgreater or = 3 antimicrobials; of 8 isolates from controls, 1 was resistant. Resistance to trimethoprim-sulfamethoxazole was significantly higher among HIV-infected subjects with \textless200 CD4 cells/microL than in those with more CD4 cells. Polymerase chain reaction DNA analysis with BOX primers demonstrated that 12 HIV-infected subjects were persistently colonized with the same S. pneumoniae strain for \textgreater or = 1 month compared with none of the controls. HIV-infected subjects were more likely to be persistent pneumococcal carriers and to carry antibiotic-resistant isolates than were non-HIV-infected subjects.
@article{rodriguez-barradas_colonization_1997,
abstract = {Pharyngeal colonization by Streptococcus pneumoniae was evaluated in 103 human immunodeficiency virus {(HIV)-infected} subjects ({\textless}200 {CD4} {cells/microL,} 57; {\textgreater} or = 200 {CD4} {cells/microL,} 46) and 39 {non-HIV-infected} controls who were participants in a vaccine study. At baseline, 7\%, 20\%, and 10\% of subjects in the {\textless}200 and {\textgreater} or = 200 {CD4} cell groups and in the control group were colonized with S. pneumoniae: Rates at 6 months were 23\%, 22\%, and 0\%, respectively. Of 34 isolates from {HIV-infected} subjects, 25 were penicillin-resistant and 19 were resistant to {\textgreater} or = 3 antimicrobials; of 8 isolates from controls, 1 was resistant. Resistance to trimethoprim-sulfamethoxazole was significantly higher among {HIV-infected} subjects with {\textless}200 {CD4} {cells/microL} than in those with more {CD4} cells. Polymerase chain reaction {DNA} analysis with {BOX} primers demonstrated that 12 {HIV-infected} subjects were persistently colonized with the same S. pneumoniae strain for {\textgreater} or = 1 month compared with none of the controls. {HIV-infected} subjects were more likely to be persistent pneumococcal carriers and to carry antibiotic-resistant isolates than were {non-HIV-infected} subjects.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {{Rodriguez-Barradas}, M C and Tharapel, R A and Groover, J E and Giron, K P and Lacke, C E and Houston, E D and Hamill, R J and Steinhoff, M C and Musher, D M},
biburl = {https://www.bibsonomy.org/bibtex/2481d4747ba94fd78c771511f09274c54/jelias},
interhash = {3875b6908f82c978e43cd6e0eb9e8dda},
intrahash = {481d4747ba94fd78c771511f09274c54},
issn = {0022-1899},
journal = {The Journal of Infectious Diseases},
keywords = {Adult, Aged, Bacterial, Carrier Chain Count, Drug Factors, Humans, Infections, Lymphocyte Male, Microbial, Middle Pharyngitis, Pharynx, Polymerase Reaction, Resistance, Risk State, Streptococcal Streptococcus pneumoniae {CD4} {DNA,} {HIV}},
month = mar,
note = {{PMID:} 9041330},
number = 3,
pages = {590--7},
shorttitle = {Colonization by Streptococcus pneumoniae among human immunodeficiency virus-infected adults},
timestamp = {2011-03-11T10:06:47.000+0100},
title = {Colonization by Streptococcus pneumoniae among human immunodeficiency virus-infected adults: prevalence of antibiotic resistance, impact of immunization, and characterization by polymerase chain reaction with {BOX} primers of isolates from persistent S. pneumoniae carriers},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9041330},
volume = 175,
year = 1997
}