%0 Journal Article %1 Kashef:2009:Genes-Dev:19528317 %A Kashef, J %A Köhler, A %A Kuriyama, S %A Alfandari, D %A Mayor, R %A Wedlich, D %D 2009 %J Genes Dev %K biology development xenopus %N 12 %P 1393-1398 %R 10.1101/gad.519409 %T Cadherin-11 regulates protrusive activity in Xenopus cranial neural crest cells upstream of Trio and the small GTPases %U http://www.ncbi.nlm.nih.gov/pubmed/19528317 %V 23 %X Xenopus Cadherin-11 (Xcad-11) is expressed when cranial neural crest cells (CNC) acquire motility. However, its function in stimulating cell migration is poorly understood. Here, we demonstrate that Xcad-11 initiates filopodia and lamellipodia formation, which is essential for CNC to populate pharyngeal pouches. We identified the cytoplasmic tail of Xcad-11 as both necessary and sufficient for proper CNC migration as long as it was linked to the plasma membrane. Our results showing that guanine nucleotide exchange factor (GEF)-Trio binds to Xcad-11 and can functionally substitute for it like constitutively active forms of RhoA, Rac, and cdc42 unravel a novel cadherin function.

@article{Kashef:2009:Genes-Dev:19528317, abstract = {Xenopus Cadherin-11 (Xcad-11) is expressed when cranial neural crest cells (CNC) acquire motility. However, its function in stimulating cell migration is poorly understood. Here, we demonstrate that Xcad-11 initiates filopodia and lamellipodia formation, which is essential for CNC to populate pharyngeal pouches. We identified the cytoplasmic tail of Xcad-11 as both necessary and sufficient for proper CNC migration as long as it was linked to the plasma membrane. Our results showing that guanine nucleotide exchange factor (GEF)-Trio binds to Xcad-11 and can functionally substitute for it like constitutively active forms of RhoA, Rac, and cdc42 unravel a novel cadherin function.}, added-at = {2014-09-09T18:33:13.000+0200}, author = {Kashef, J and K{\"o}hler, A and Kuriyama, S and Alfandari, D and Mayor, R and Wedlich, D}, biburl = {https://www.bibsonomy.org/bibtex/250f79723e9d68d5359c94dbd331639e2/alex_ruff}, description = {Cadherin-11 regulates protrusive activity in Xenop... [Genes Dev. 2009] - PubMed - NCBI}, doi = {10.1101/gad.519409}, interhash = {6f79e86be7992a6fc86d6c032259d2c0}, intrahash = {50f79723e9d68d5359c94dbd331639e2}, journal = {Genes Dev}, keywords = {biology development xenopus}, month = jun, number = 12, pages = {1393-1398}, pmid = {19528317}, timestamp = {2014-09-09T18:33:13.000+0200}, title = {Cadherin-11 regulates protrusive activity in Xenopus cranial neural crest cells upstream of Trio and the small GTPases}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19528317}, volume = 23, year = 2009 }