Interaural Phase and Level Difference Sensitivity in Low-Frequency
Neurons in the Lateral Superior Olive
D. Tollin, and T. Yin. The Journal of Neuroscience, November, (2005)
Abstract
The lateral superior olive (LSO) is believed to encode differences
in sound level at the two ears, a cue for azimuthal sound location.
Most high-frequency-sensitive LSO neurons are binaural, receiving
inputs from both ears. An inhibitory input from the contralateral
ear, via the medial nucleus of the trapezoid body (MNTB), and excitatory
input from the ipsilateral ear enable level differences to be encoded.
However, the classical descriptions of low-frequency-sensitive neurons
report primarily monaural cells with no contralateral inhibition.
Anatomical and physiological evidence, however, shows that low-frequency
LSO neurons receive low-frequency inhibitory input from ipsilateral
MNTB, which in turn receives excitatory input from the contralateral
cochlear nucleus and low-frequency excitatory input from the ipsilateral
cochlear nucleus. Therefore, these neurons would be expected to be
binaural with contralateral inhibition. Here, we re-examined binaural
interaction in low-frequency (less than approximately 3 kHz) LSO
neurons and phase locking in the MNTB. Phase locking to low-frequency
tones in MNTB and ipsilaterally driven LSO neurons with frequency
sensitivities <1.2 kHz was enhanced relative to the auditory nerve.
Moreover, most low-frequency LSO neurons exhibited contralateral
inhibition: ipsilaterally driven responses were suppressed by raising
the level of the contralateral stimulus; most neurons were sensitive
to interaural time delays in pure tone and noise stimuli such that
inhibition was nearly maximal when the stimuli were presented to
the ears in-phase. The data demonstrate that low-frequency LSO neurons
of cat are not monaural and can exhibit contralateral inhibition
like their high-frequency counterparts.
2005\Interaural Phase and Level Difference Sensitivity in Low-Frequency Neurons in the Lateral Superior Olive.pdf
file
Interaural Phase and Level Difference Sensitivity in Low-Frequency Neurons in the Lateral Superior Olive.pdf:2005\\Interaural Phase and Level Difference Sensitivity in Low-Frequency Neurons in the Lateral Superior Olive.pdf:PDF
%0 Journal Article
%1 Tollin2005
%A Tollin, Daniel J.
%A Yin, TomC. T.
%D 2005
%J The Journal of Neuroscience, November
%K body, delay, difference, interaural lateral level localization,phase locking medial nucleus of olive, sound superior the time trapezoid
%P 10648–10657
%T Interaural Phase and Level Difference Sensitivity in Low-Frequency
Neurons in the Lateral Superior Olive
%V 25
%X The lateral superior olive (LSO) is believed to encode differences
in sound level at the two ears, a cue for azimuthal sound location.
Most high-frequency-sensitive LSO neurons are binaural, receiving
inputs from both ears. An inhibitory input from the contralateral
ear, via the medial nucleus of the trapezoid body (MNTB), and excitatory
input from the ipsilateral ear enable level differences to be encoded.
However, the classical descriptions of low-frequency-sensitive neurons
report primarily monaural cells with no contralateral inhibition.
Anatomical and physiological evidence, however, shows that low-frequency
LSO neurons receive low-frequency inhibitory input from ipsilateral
MNTB, which in turn receives excitatory input from the contralateral
cochlear nucleus and low-frequency excitatory input from the ipsilateral
cochlear nucleus. Therefore, these neurons would be expected to be
binaural with contralateral inhibition. Here, we re-examined binaural
interaction in low-frequency (less than approximately 3 kHz) LSO
neurons and phase locking in the MNTB. Phase locking to low-frequency
tones in MNTB and ipsilaterally driven LSO neurons with frequency
sensitivities <1.2 kHz was enhanced relative to the auditory nerve.
Moreover, most low-frequency LSO neurons exhibited contralateral
inhibition: ipsilaterally driven responses were suppressed by raising
the level of the contralateral stimulus; most neurons were sensitive
to interaural time delays in pure tone and noise stimuli such that
inhibition was nearly maximal when the stimuli were presented to
the ears in-phase. The data demonstrate that low-frequency LSO neurons
of cat are not monaural and can exhibit contralateral inhibition
like their high-frequency counterparts.
@article{Tollin2005,
abstract = {The lateral superior olive (LSO) is believed to encode differences
in sound level at the two ears, a cue for azimuthal sound location.
Most high-frequency-sensitive LSO neurons are binaural, receiving
inputs from both ears. An inhibitory input from the contralateral
ear, via the medial nucleus of the trapezoid body (MNTB), and excitatory
input from the ipsilateral ear enable level differences to be encoded.
However, the classical descriptions of low-frequency-sensitive neurons
report primarily monaural cells with no contralateral inhibition.
Anatomical and physiological evidence, however, shows that low-frequency
LSO neurons receive low-frequency inhibitory input from ipsilateral
MNTB, which in turn receives excitatory input from the contralateral
cochlear nucleus and low-frequency excitatory input from the ipsilateral
cochlear nucleus. Therefore, these neurons would be expected to be
binaural with contralateral inhibition. Here, we re-examined binaural
interaction in low-frequency (less than approximately 3 kHz) LSO
neurons and phase locking in the MNTB. Phase locking to low-frequency
tones in MNTB and ipsilaterally driven LSO neurons with frequency
sensitivities <1.2 kHz was enhanced relative to the auditory nerve.
Moreover, most low-frequency LSO neurons exhibited contralateral
inhibition: ipsilaterally driven responses were suppressed by raising
the level of the contralateral stimulus; most neurons were sensitive
to interaural time delays in pure tone and noise stimuli such that
inhibition was nearly maximal when the stimuli were presented to
the ears in-phase. The data demonstrate that low-frequency LSO neurons
of cat are not monaural and can exhibit contralateral inhibition
like their high-frequency counterparts.},
added-at = {2012-01-27T14:10:42.000+0100},
author = {Tollin, Daniel J. and Yin, TomC. T.},
biburl = {https://www.bibsonomy.org/bibtex/253ecad5a04c5b4dd652155db53a11fd8/muhe},
file = {Interaural Phase and Level Difference Sensitivity in Low-Frequency Neurons in the Lateral Superior Olive.pdf:2005\\Interaural Phase and Level Difference Sensitivity in Low-Frequency Neurons in the Lateral Superior Olive.pdf:PDF},
interhash = {242ceec1ccfefd29c3c180d274842728},
intrahash = {53ecad5a04c5b4dd652155db53a11fd8},
journal = {The Journal of Neuroscience, November},
keywords = {body, delay, difference, interaural lateral level localization,phase locking medial nucleus of olive, sound superior the time trapezoid},
owner = {Mu},
pages = {10648–10657},
pdf = {2005\Interaural Phase and Level Difference Sensitivity in Low-Frequency Neurons in the Lateral Superior Olive.pdf},
timestamp = {2012-01-27T14:11:14.000+0100},
title = {Interaural Phase and Level Difference Sensitivity in Low-Frequency
Neurons in the Lateral Superior Olive},
volume = 25,
year = 2005
}