%0 Journal Article %1 citeulike:565407 %A Navajas, M. %A Laurent, A. M. %A Moreel, J. F. %A Ragab, A. %A Cambou, J. P. %A Cuny, G. %A Cambien, F. %A Roizès, G. %C CNRS UPR 8402, Institut de Biologie, Montpellier, France. %D 1990 %J Hum Genet %K polymorphism sequence apob %N 1 %P 91--93 %R 10.1007/BF00205183 %T Detection by denaturing gradient gel electrophoresis of a new polymorphism in the apolipoprotein B gene. %U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1979313 %V 86 %X The apolipoprotein B gene is subject to mutations that may be important in coronary heart diseases. We have used polymerase chain reaction and denaturing gradient gel electrophoresis to characterize a single nucleotide substitution in the apolipoprotein B gene. This mutation affects amino acid 4311 of the protein and converts asparagine to serine. It was found in 24% of the 81 unrelated individuals analyzed. Moreover, another mutation was detected by sequencing in a single individual.

@article{citeulike:565407, abstract = {The apolipoprotein B gene is subject to mutations that may be important in coronary heart diseases. We have used polymerase chain reaction and denaturing gradient gel electrophoresis to characterize a single nucleotide substitution in the apolipoprotein B gene. This mutation affects amino acid 4311 of the protein and converts asparagine to serine. It was found in 24% of the 81 unrelated individuals analyzed. Moreover, another mutation was detected by sequencing in a single individual.}, added-at = {2006-07-07T01:10:50.000+0200}, address = {CNRS UPR 8402, Institut de Biologie, Montpellier, France.}, author = {Navajas, M. and Laurent, A. M. and Moreel, J. F. and Ragab, A. and Cambou, J. P. and Cuny, G. and Cambien, F. and Roizès, G.}, biburl = {https://www.bibsonomy.org/bibtex/2540cdd59927eadc8fa2806983bf480a9/biblio24}, citeulike-article-id = {565407}, doi = {10.1007/BF00205183}, interhash = {52351cb77ca100050a9141548b1b69dd}, intrahash = {540cdd59927eadc8fa2806983bf480a9}, issn = {0340-6717}, journal = {Hum Genet}, keywords = {polymorphism sequence apob}, month = {November}, number = 1, pages = {91--93}, priority = {2}, timestamp = {2006-07-07T01:10:50.000+0200}, title = {Detection by denaturing gradient gel electrophoresis of a new polymorphism in the apolipoprotein B gene.}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve\&db=pubmed\&dopt=Abstract\&list_uids=1979313}, volume = 86, year = 1990 }