Growth and development can be investigated using readily observable demographic factors such as weight and age. Size is the primary covariate and can be referenced to a 70-kg person with allometry using a coefficient of 0.75 for clearance and 1 for volume. The use of these coefficients is supported by fractal geometric concepts and observations from diverse areas in biology. Fat free mass (FFM) might be expected to do better than total body weight when there are wide variations in fat affecting body composition. Clearance pathways develop in the fetus before birth. The use of postnatal age as a descriptor of maturation is unsatisfactory because birth may occur prematurely; therefore postmenstrual age is a superior predictor of elimination function. A sigmoid E(max) model (Hill equation) describes gradual maturation of clearance in early life leading to a mature adult clearance achieved at a later age.
%0 Journal Article
%1 Anderson.2008
%A Anderson, B. J.
%A Holford, N. H. G.
%D 2008
%J Annual review of pharmacology and toxicology
%K & Adolescent Adult Age Biological Body Child Child, Compositionphysiology Dose-Response Drug Factors Humans Infant Infant, Models, Newborn Pharmaceutical Pharmacokinetics Preparationsadministration Preschool Relationship, Sizephysiology Weightphysiology dosage
%P 303-332
%T Mechanism-based concepts of size and maturity in pharmacokinetics
%U doi:10.1146/annurev.pharmtox.48.113006.094708
%V 48
%X Growth and development can be investigated using readily observable demographic factors such as weight and age. Size is the primary covariate and can be referenced to a 70-kg person with allometry using a coefficient of 0.75 for clearance and 1 for volume. The use of these coefficients is supported by fractal geometric concepts and observations from diverse areas in biology. Fat free mass (FFM) might be expected to do better than total body weight when there are wide variations in fat affecting body composition. Clearance pathways develop in the fetus before birth. The use of postnatal age as a descriptor of maturation is unsatisfactory because birth may occur prematurely; therefore postmenstrual age is a superior predictor of elimination function. A sigmoid E(max) model (Hill equation) describes gradual maturation of clearance in early life leading to a mature adult clearance achieved at a later age.
@article{Anderson.2008,
abstract = {Growth and development can be investigated using readily observable demographic factors such as weight and age. Size is the primary covariate and can be referenced to a 70-kg person with allometry using a coefficient of 0.75 for clearance and 1 for volume. The use of these coefficients is supported by fractal geometric concepts and observations from diverse areas in biology. Fat free mass (FFM) might be expected to do better than total body weight when there are wide variations in fat affecting body composition. Clearance pathways develop in the fetus before birth. The use of postnatal age as a descriptor of maturation is unsatisfactory because birth may occur prematurely; therefore postmenstrual age is a superior predictor of elimination function. A sigmoid E(max) model (Hill equation) describes gradual maturation of clearance in early life leading to a mature adult clearance achieved at a later age.},
added-at = {2010-02-04T16:31:48.000+0100},
author = {Anderson, B. J. and Holford, N. H. G.},
biburl = {https://www.bibsonomy.org/bibtex/2541bb72e83d8519c1f133725649bf38b/hruehs},
interhash = {39b5bc4b8e62cb5e6d21d5befda8067a},
intrahash = {541bb72e83d8519c1f133725649bf38b},
issn = {0362-1642},
journal = {Annual review of pharmacology and toxicology},
keywords = {& Adolescent Adult Age Biological Body Child Child, Compositionphysiology Dose-Response Drug Factors Humans Infant Infant, Models, Newborn Pharmaceutical Pharmacokinetics Preparationsadministration Preschool Relationship, Sizephysiology Weightphysiology dosage},
pages = {303-332},
timestamp = {2010-02-04T16:31:51.000+0100},
title = {Mechanism-based concepts of size and maturity in pharmacokinetics},
url = {doi:10.1146/annurev.pharmtox.48.113006.094708},
volume = 48,
year = 2008
}