%0 Journal Article %1 Cross.2003 %A Cross, M. J. %A Dixelius, J. %A Matsumoto, T. %A Claesson-Welsh, L. %D 2003 %J Trends Biochem.Sci. %K Adult Animals Cells Endothelial Factor Growth Hematopoietic Humans Ligands Lymphangiogenesis Lymphatic Metastasis Neovascularization Pathologic Physiologic Receptors Research Signal Specificity Stem Substrate Transduction Vascular genetics metabolism pathology physiology physiopathology therapy %N 9 %P 488-494 %T VEGF-receptor signal transduction %U PM:13678960 %V 28 %X The vascular endothelial growth factor (VEGF) family of ligands and receptors has been the focus of attention in vascular biology for more than a decade. There is now a consensus that the VEGFs are crucial for vascular development and neovascularization in physiological and pathological processes in both embryo and adult. This has facilitated a rapid transition to their use in clinical applications, for example, administration of VEGF ligands to enhance vascularization of ischaemic tissues and, conversely, inhibitors of VEGF-receptor function in anti-angiogenic therapy. More recent data indicate essential roles for the VEGFs in haematopoietic cell function and in lymphangiogenesis

@article{Cross.2003, abstract = {The vascular endothelial growth factor (VEGF) family of ligands and receptors has been the focus of attention in vascular biology for more than a decade. There is now a consensus that the VEGFs are crucial for vascular development and neovascularization in physiological and pathological processes in both embryo and adult. This has facilitated a rapid transition to their use in clinical applications, for example, administration of VEGF ligands to enhance vascularization of ischaemic tissues and, conversely, inhibitors of VEGF-receptor function in anti-angiogenic therapy. More recent data indicate essential roles for the VEGFs in haematopoietic cell function and in lymphangiogenesis}, added-at = {2010-02-05T11:28:39.000+0100}, author = {Cross, M. J. and Dixelius, J. and Matsumoto, T. and Claesson-Welsh, L.}, biburl = {https://www.bibsonomy.org/bibtex/2d76fa68992371a755810c81e7ffe5219/kanefendt}, interhash = {2580b5615e2ed4c1a81b6fc5a532a139}, intrahash = {d76fa68992371a755810c81e7ffe5219}, journal = {Trends Biochem.Sci.}, keywords = {Adult Animals Cells Endothelial Factor Growth Hematopoietic Humans Ligands Lymphangiogenesis Lymphatic Metastasis Neovascularization Pathologic Physiologic Receptors Research Signal Specificity Stem Substrate Transduction Vascular genetics metabolism pathology physiology physiopathology therapy}, number = 9, pages = {488-494}, timestamp = {2010-02-05T11:28:41.000+0100}, title = {VEGF-receptor signal transduction}, url = {PM:13678960}, volume = 28, year = 2003 }