Systems Biology is the quantitative analysis of dynamic interactions among several components of a biochemical system, aiming at an understanding of the behavior of the system as a whole. From an experimental perspective, systems biology is a suitable tool to support the biologist in the process of hypotheses generation and the efficient design of experiments. In this chapter, we discuss the elements of a systems biology methodology based on the interaction between experimental biologists and theoreticians. We, furthermore, show the use of such a methodology in a case study, analyzing receptor and transcription factor modulation affecting the responsiveness of the JAK2/STAT5 pathway.
%0 Journal Article
%1 vera_system_2008
%A Vera, Julio
%A Wolkenhauer, Olaf
%D 2008
%J Methods in Cell Biology
%K 2, Biological, Calibration, Cell Communication, Computer Dynamics, Erythropoietin, Factor, Janus Kinase Models, Nonlinear Receptors, Rostock SBI Signal Simulation, Systems Transcription Transduction, biology {STAT5}
%P 399--415
%R 10.1016/S0091-679X(08)00817-0
%T A system biology approach to understand functional activity of cell communication systems
%U http://www.ncbi.nlm.nih.gov/pubmed/19195559
%V 90
%X Systems Biology is the quantitative analysis of dynamic interactions among several components of a biochemical system, aiming at an understanding of the behavior of the system as a whole. From an experimental perspective, systems biology is a suitable tool to support the biologist in the process of hypotheses generation and the efficient design of experiments. In this chapter, we discuss the elements of a systems biology methodology based on the interaction between experimental biologists and theoreticians. We, furthermore, show the use of such a methodology in a case study, analyzing receptor and transcription factor modulation affecting the responsiveness of the JAK2/STAT5 pathway.
@article{vera_system_2008,
abstract = {Systems Biology is the quantitative analysis of dynamic interactions among several components of a biochemical system, aiming at an understanding of the behavior of the system as a whole. From an experimental perspective, systems biology is a suitable tool to support the biologist in the process of hypotheses generation and the efficient design of experiments. In this chapter, we discuss the elements of a systems biology methodology based on the interaction between experimental biologists and theoreticians. We, furthermore, show the use of such a methodology in a case study, analyzing receptor and transcription factor modulation affecting the responsiveness of the {JAK2/STAT5} pathway.},
added-at = {2010-09-21T13:55:45.000+0200},
author = {Vera, Julio and Wolkenhauer, Olaf},
biburl = {https://www.bibsonomy.org/bibtex/272e18360a67f14e2e221371b78f80dac/ra1602},
doi = {10.1016/S0091-679X(08)00817-0},
interhash = {d8b9710071f30dd05ef0ef8aa486dacb},
intrahash = {72e18360a67f14e2e221371b78f80dac},
issn = {{0091-679X}},
journal = {Methods in Cell Biology},
keywords = {2, Biological, Calibration, Cell Communication, Computer Dynamics, Erythropoietin, Factor, Janus Kinase Models, Nonlinear Receptors, Rostock SBI Signal Simulation, Systems Transcription Transduction, biology {STAT5}},
note = {{PMID:} 19195559},
pages = {399--415},
timestamp = {2010-09-21T13:55:46.000+0200},
title = {A system biology approach to understand functional activity of cell communication systems},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19195559},
volume = 90,
year = 2008
}