%0 Journal Article %1 Thomas.2013 %A Thomas, Stephanie %A Kratzsch, Dorothea %A Schaab, Michael %A Scholz, Markus %A Grunewald, Sonja %A Thiery, Joachim %A Paasch, Uwe %A Kratzsch, Juergen %D 2013 %J Fertility and sterility %K Adipokines/blood/metabolism Adiponectin/blood/metabolism Adult Body_Weight/physiology Chemokines/blood/metabolism Cross-Sectional_Studies Cytokines/blood/metabolism Fertility/physiology Humans Intercellular_Signaling_Peptides_and_Proteins/blood/metabolism Leptin/blood/metabolism Male Middle_Aged Nicotinamide_Phosphoribosyltransferase/blood/metabolism Obesity/metabolism Overweight/metabolism Resistin/blood/metabolism Semen/metabolism Serpins/blood/metabolism Spermatozoa/cytology/physiology Young_Adult %N 5 %P 1256-1263.e3 %T Seminal plasma adipokine levels are correlated with functional characteristics of spermatozoa %V 99 %X OBJECTIVE\r\nTo study adipokines as a potential link between obesity and male subfertility.\r\nDESIGN\r\nCross-sectional study of subjects stratified into subgroups according to body mass index (BMI): normal-weight (18.50-24.99 kg/m(2)), overweight (25-29.99 kg/m(2)), and obese (>30 kg/m(2)).\r\nSETTING\r\nLeipzig, Germany from 2007 to 2011.\r\nPATIENT(S)\r\nNinety-six male volunteers without spermatogenesis-associated diseases.\r\nINTERVENTION(S)\r\nNone.\r\nMAIN OUTCOME MEASURE(S)\r\nSemen parameters, reproductive hormones in serum, and leptin, adiponectin, resistin, chemerin, progranulin, vaspin, and visfatin concentrations in serum and seminal plasma.\r\nRESULT(S)\r\nAll measured adipokines were detectable in human seminal plasma. The levels of progranulin, visfatin, and vaspin were statistically significantly higher in seminal plasma than in serum. An increase in body weight was associated with decreased levels of seminal plasma progranulin. Additionally, overweight/obese men had statistically significantly lower progranulin levels in seminal plasma than normal weight men. Adiponectin and progranulin concentrations in seminal plasma statistically significantly positively correlated with sperm concentration, sperm count, and total normomorphic spermatozoa.\r\nCONCLUSION(S)\r\nAdipokines are differently regulated in human male reproductive tract compared with the peripheral blood, and they could influence sperm functionality.

@article{Thomas.2013, abstract = {OBJECTIVE\r\nTo study adipokines as a potential link between obesity and male subfertility.\r\nDESIGN\r\nCross-sectional study of subjects stratified into subgroups according to body mass index (BMI): normal-weight (18.50-24.99 kg/m(2)), overweight (25-29.99 kg/m(2)), and obese (>30 kg/m(2)).\r\nSETTING\r\nLeipzig, Germany from 2007 to 2011.\r\nPATIENT(S)\r\nNinety-six male volunteers without spermatogenesis-associated diseases.\r\nINTERVENTION(S)\r\nNone.\r\nMAIN OUTCOME MEASURE(S)\r\nSemen parameters, reproductive hormones in serum, and leptin, adiponectin, resistin, chemerin, progranulin, vaspin, and visfatin concentrations in serum and seminal plasma.\r\nRESULT(S)\r\nAll measured adipokines were detectable in human seminal plasma. The levels of progranulin, visfatin, and vaspin were statistically significantly higher in seminal plasma than in serum. An increase in body weight was associated with decreased levels of seminal plasma progranulin. Additionally, overweight/obese men had statistically significantly lower progranulin levels in seminal plasma than normal weight men. Adiponectin and progranulin concentrations in seminal plasma statistically significantly positively correlated with sperm concentration, sperm count, and total normomorphic spermatozoa.\r\nCONCLUSION(S)\r\nAdipokines are differently regulated in human male reproductive tract compared with the peripheral blood, and they could influence sperm functionality.}, added-at = {2014-10-13T18:25:04.000+0200}, author = {Thomas, Stephanie and Kratzsch, Dorothea and Schaab, Michael and Scholz, Markus and Grunewald, Sonja and Thiery, Joachim and Paasch, Uwe and Kratzsch, Juergen}, biburl = {https://www.bibsonomy.org/bibtex/2760b0608b31e1bc84284e8b5b85990ad/drtester}, interhash = {53a94c75053f16fe84a5d8f4afd0da1b}, intrahash = {760b0608b31e1bc84284e8b5b85990ad}, journal = {Fertility and sterility}, keywords = {Adipokines/blood/metabolism Adiponectin/blood/metabolism Adult Body_Weight/physiology Chemokines/blood/metabolism Cross-Sectional_Studies Cytokines/blood/metabolism Fertility/physiology Humans Intercellular_Signaling_Peptides_and_Proteins/blood/metabolism Leptin/blood/metabolism Male Middle_Aged Nicotinamide_Phosphoribosyltransferase/blood/metabolism Obesity/metabolism Overweight/metabolism Resistin/blood/metabolism Semen/metabolism Serpins/blood/metabolism Spermatozoa/cytology/physiology Young_Adult}, number = 5, pages = {1256-1263.e3}, timestamp = {2014-10-13T18:25:04.000+0200}, title = {Seminal plasma adipokine levels are correlated with functional characteristics of spermatozoa}, volume = 99, year = 2013 }