Cardiac excitation-contraction coupling.
Nature, 415 (6868):
198--205 (January 2002)DOI: 10.1038/415198a
Abstract
Of the ions involved in the intricate workings of the heart, calcium
is considered perhaps the most important. It is crucial to the very
process that enables the chambers of the heart to contract and relax,
a process called excitation-contraction coupling. It is important
to understand in quantitative detail exactly how calcium is moved
around the various organelles of the myocyte in order to bring about
excitation-contraction coupling if we are to understand the basic
physiology of heart function. Furthermore, spatial microdomains within
the cell are important in localizing the molecular players that orchestrate
cardiac function.
Description
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