Of huge importance now is to provide a fast, cost-effective, safe, and immediately available pharmaceutical solution to curb the rapid global spread of SARS-CoV-2. Recent publications on SARS-CoV-2 have brought attention to the possible benefit of chloroquine in the treatment of patients infected by SARS-CoV-2. Whether chloroquine can treat SARS-CoV-2 alone and also work as a prophylactic is doubtful. An effective prophylactic medication to prevent viral entry has to contain, at least, either a protease inhibitor or a competitive virus ACE2-binding inhibitor. Using bromhexine at a dosage that selectively inhibits TMPRSS2 and, in so doing, inhibits TMPRSS2-specific viral entry is likely to be effective against SARS-CoV-2. We propose the use of bromhexine as a prophylactic and treatment. We encourage the scientific community to assess bromhexine clinically as a prophylactic and curative treatment. If proven to be effective, this would allow a rapid, accessible, and cost-effective application worldwide.
Описание
Potential new treatment strategies for COVID-19: is there a role for bromhexine as add-on therapy? | SpringerLink
%0 Journal Article
%1 depfenhart2020potential
%A Depfenhart, Markus
%A de Villiers, Danielle
%A Lemperle, Gottfried
%A Meyer, Markus
%A Di Somma, Salvatore
%D 2020
%J Internal and Emergency Medicine
%K (h)cq bromhexine covid-19
%N 5
%P 801--812
%R 10.1007/s11739-020-02383-3
%T Potential new treatment strategies for COVID-19: is there a role for bromhexine as add-on therapy?
%U https://doi.org/10.1007/s11739-020-02383-3
%V 15
%X Of huge importance now is to provide a fast, cost-effective, safe, and immediately available pharmaceutical solution to curb the rapid global spread of SARS-CoV-2. Recent publications on SARS-CoV-2 have brought attention to the possible benefit of chloroquine in the treatment of patients infected by SARS-CoV-2. Whether chloroquine can treat SARS-CoV-2 alone and also work as a prophylactic is doubtful. An effective prophylactic medication to prevent viral entry has to contain, at least, either a protease inhibitor or a competitive virus ACE2-binding inhibitor. Using bromhexine at a dosage that selectively inhibits TMPRSS2 and, in so doing, inhibits TMPRSS2-specific viral entry is likely to be effective against SARS-CoV-2. We propose the use of bromhexine as a prophylactic and treatment. We encourage the scientific community to assess bromhexine clinically as a prophylactic and curative treatment. If proven to be effective, this would allow a rapid, accessible, and cost-effective application worldwide.
@article{depfenhart2020potential,
abstract = {Of huge importance now is to provide a fast, cost-effective, safe, and immediately available pharmaceutical solution to curb the rapid global spread of SARS-CoV-2. Recent publications on SARS-CoV-2 have brought attention to the possible benefit of chloroquine in the treatment of patients infected by SARS-CoV-2. Whether chloroquine can treat SARS-CoV-2 alone and also work as a prophylactic is doubtful. An effective prophylactic medication to prevent viral entry has to contain, at least, either a protease inhibitor or a competitive virus ACE2-binding inhibitor. Using bromhexine at a dosage that selectively inhibits TMPRSS2 and, in so doing, inhibits TMPRSS2-specific viral entry is likely to be effective against SARS-CoV-2. We propose the use of bromhexine as a prophylactic and treatment. We encourage the scientific community to assess bromhexine clinically as a prophylactic and curative treatment. If proven to be effective, this would allow a rapid, accessible, and cost-effective application worldwide.},
added-at = {2021-01-15T16:08:34.000+0100},
author = {Depfenhart, Markus and de Villiers, Danielle and Lemperle, Gottfried and Meyer, Markus and Di Somma, Salvatore},
biburl = {https://www.bibsonomy.org/bibtex/28a5ca3149c27736249452e4c2dfbe409/fordham1},
day = 01,
description = {Potential new treatment strategies for COVID-19: is there a role for bromhexine as add-on therapy? | SpringerLink},
doi = {10.1007/s11739-020-02383-3},
interhash = {46c1614bcb122891ffc0c886279d21ba},
intrahash = {8a5ca3149c27736249452e4c2dfbe409},
issn = {1970-9366},
journal = {Internal and Emergency Medicine},
keywords = {(h)cq bromhexine covid-19},
month = aug,
number = 5,
pages = {801--812},
timestamp = {2021-01-15T16:08:34.000+0100},
title = {Potential new treatment strategies for COVID-19: is there a role for bromhexine as add-on therapy?},
url = {https://doi.org/10.1007/s11739-020-02383-3},
volume = 15,
year = 2020
}