%0 Journal Article %1 verhaakintegrated %A Verhaak, Roel G.W %A Hoadley, Katherine A. %A Purdom, Elizabeth %A Wang, Victoria %A Qi, Yuan %A Wilkerson, Matthew D. %A Miller, C. Ryan %A Ding, Li %A Golub, Todd %A Mesirov, Jill P. %A Alexe, Gabriele %A Lawrence, Michael %A O'Kelly, Michael %A Tamayo, Pablo %A Weir, Barbara A. %A Gabriel, Stacey %A Winckler, Wendy %A Gupta, Supriya %A Jakkula, Lakshmi %A Feiler, Heidi S. %A Hodgson, J. Graeme %A James, C. David %A Sarkaria, Jann N. %A Brennan, Cameron %A Kahn, Ari %A Spellman, Paul T. %A Wilson, Richard K. %A Speed, Terence P. %A Gray, Joe W. %A Meyerson, Matthew %A Getz, Gad %A Perou, Charles M. %A Hayes, D. Neil %B Cancer Cell %D 2010 %I Elsevier %J Cancer Cell %K cancer-research glioblastoma glioma %N 1 %P 98--110 %R 10.1016/j.ccr.2009.12.020 %T Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in <em>PDGFRA</em>, <em>IDH1</em>, <em>EGFR</em>, and <em>NF1</em> %U http://dx.doi.org/10.1016/j.ccr.2009.12.020 %V 17 %X The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes and integrate multidimensional genomic data to establish patterns of somatic mutations and DNA copy number. Aberrations and gene expression of EGFR, NF1, and PDGFRA/IDH1 each define the Classical, Mesenchymal, and Proneural subtypes, respectively. Gene signatures of normal brain cell types show a strong relationship between subtypes and different neural lineages. Additionally, response to aggressive therapy differs by subtype, with the greatest benefit in the Classical subtype and no benefit in the Proneural subtype. We provide a framework that unifies transcriptomic and genomic dimensions for GBM molecular stratification with important implications for future studies.

@article{verhaakintegrated, abstract = {The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes and integrate multidimensional genomic data to establish patterns of somatic mutations and DNA copy number. Aberrations and gene expression of EGFR, NF1, and PDGFRA/IDH1 each define the Classical, Mesenchymal, and Proneural subtypes, respectively. Gene signatures of normal brain cell types show a strong relationship between subtypes and different neural lineages. Additionally, response to aggressive therapy differs by subtype, with the greatest benefit in the Classical subtype and no benefit in the Proneural subtype. We provide a framework that unifies transcriptomic and genomic dimensions for GBM molecular stratification with important implications for future studies.}, added-at = {2017-09-29T20:16:03.000+0200}, author = {Verhaak, Roel G.W and Hoadley, Katherine A. and Purdom, Elizabeth and Wang, Victoria and Qi, Yuan and Wilkerson, Matthew D. and Miller, C. Ryan and Ding, Li and Golub, Todd and Mesirov, Jill P. and Alexe, Gabriele and Lawrence, Michael and O'Kelly, Michael and Tamayo, Pablo and Weir, Barbara A. and Gabriel, Stacey and Winckler, Wendy and Gupta, Supriya and Jakkula, Lakshmi and Feiler, Heidi S. and Hodgson, J. Graeme and James, C. David and Sarkaria, Jann N. and Brennan, Cameron and Kahn, Ari and Spellman, Paul T. and Wilson, Richard K. and Speed, Terence P. and Gray, Joe W. and Meyerson, Matthew and Getz, Gad and Perou, Charles M. and Hayes, D. Neil}, biburl = {https://www.bibsonomy.org/bibtex/28d802a11539687ed45264155c4625091/marcsaric}, booktitle = {Cancer Cell}, comment = {doi: 10.1016/j.ccr.2009.12.020}, description = {Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1: Cancer Cell}, doi = {10.1016/j.ccr.2009.12.020}, interhash = {e5d6b8d418f8c511f4adca78d38235ee}, intrahash = {8d802a11539687ed45264155c4625091}, issn = {15356108}, journal = {Cancer Cell}, keywords = {cancer-research glioblastoma glioma}, number = 1, pages = {98--110}, publisher = {Elsevier}, timestamp = {2017-09-29T20:16:03.000+0200}, title = {Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in <em>PDGFRA</em>, <em>IDH1</em>, <em>EGFR</em>, and <em>NF1</em>}, url = {http://dx.doi.org/10.1016/j.ccr.2009.12.020}, volume = 17, year = 2010 }