M-FISH KARYOTYPING - A NEW APPROACH BASED ON WATERSHED TRANSFORM
S. S, L. A, and V. Govindan. International Journal of Computer Science, Engineering and Information Technology (IJCSEIT), 2 (2):
105-117(April 2012)
DOI: 10.5121/ijcseit.2012.2210
Abstract
Karyotyping is a process in which chromosomes in a dividing cell are properly stained, identified and
displayed in a standard format, which helps geneticist to study and diagnose genetic factors behind various
genetic diseases and for studying cancer. M-FISH (Multiplex Fluorescent In-Situ Hybridization) provides
color karyotyping. In this paper, an automated method for M-FISH chromosome segmentation based on
watershed transform followed by naive Bayes classification of each region using the features, mean and
standard deviation, is presented. Also, a post processing step is added to re-classify the small chromosome
segments to the neighboring larger segment for reducing the chances of misclassification. The approach
provided improved accuracy when compared to the pixel-by-pixel approach. The approach was tested on
40 images from the dataset and achieved an accuracy of 84.21 %.
%0 Journal Article
%1 noauthororeditor
%A S, Sreejini K
%A A, Lijiya
%A Govindan, V K
%D 2012
%J International Journal of Computer Science, Engineering and Information Technology (IJCSEIT)
%K Bayes Chromosome Karyotyping M-FISH Watershed classifier image segmentation transform
%N 2
%P 105-117
%R 10.5121/ijcseit.2012.2210
%T M-FISH KARYOTYPING - A NEW APPROACH BASED ON WATERSHED TRANSFORM
%U http://airccse.org/journal/ijcseit/papers/2212ijcseit10.pdf
%V 2
%X Karyotyping is a process in which chromosomes in a dividing cell are properly stained, identified and
displayed in a standard format, which helps geneticist to study and diagnose genetic factors behind various
genetic diseases and for studying cancer. M-FISH (Multiplex Fluorescent In-Situ Hybridization) provides
color karyotyping. In this paper, an automated method for M-FISH chromosome segmentation based on
watershed transform followed by naive Bayes classification of each region using the features, mean and
standard deviation, is presented. Also, a post processing step is added to re-classify the small chromosome
segments to the neighboring larger segment for reducing the chances of misclassification. The approach
provided improved accuracy when compared to the pixel-by-pixel approach. The approach was tested on
40 images from the dataset and achieved an accuracy of 84.21 %.
@article{noauthororeditor,
abstract = {Karyotyping is a process in which chromosomes in a dividing cell are properly stained, identified and
displayed in a standard format, which helps geneticist to study and diagnose genetic factors behind various
genetic diseases and for studying cancer. M-FISH (Multiplex Fluorescent In-Situ Hybridization) provides
color karyotyping. In this paper, an automated method for M-FISH chromosome segmentation based on
watershed transform followed by naive Bayes classification of each region using the features, mean and
standard deviation, is presented. Also, a post processing step is added to re-classify the small chromosome
segments to the neighboring larger segment for reducing the chances of misclassification. The approach
provided improved accuracy when compared to the pixel-by-pixel approach. The approach was tested on
40 images from the dataset and achieved an accuracy of 84.21 %.
},
added-at = {2018-07-07T08:53:45.000+0200},
author = {S, Sreejini K and A, Lijiya and Govindan, V K},
biburl = {https://www.bibsonomy.org/bibtex/28ec325477502322ec646c46a9dca186e/ijcseit},
doi = {10.5121/ijcseit.2012.2210},
interhash = {ef04b0d2f481a351a7c0564e3da8dbd0},
intrahash = {8ec325477502322ec646c46a9dca186e},
issn = {2231-3117 [Online] ; 2231-3605 [Print]},
journal = {International Journal of Computer Science, Engineering and Information Technology (IJCSEIT)},
keywords = {Bayes Chromosome Karyotyping M-FISH Watershed classifier image segmentation transform},
language = {English},
month = apr,
number = 2,
pages = {105-117},
timestamp = {2018-07-07T08:53:45.000+0200},
title = {M-FISH KARYOTYPING - A NEW APPROACH BASED ON WATERSHED TRANSFORM},
url = {http://airccse.org/journal/ijcseit/papers/2212ijcseit10.pdf},
volume = 2,
year = 2012
}