Cerebral palsy (CP) is often a consequence of a hypoxic-ischemic encephalopathy and/or intracerebral hemorrhage secondary to pre- and peri-natal asphyxia. Hypodense lesions on the CT-scan are found in about 70 to 80\% of CP-patients. In the present study, regional cerebral blood flow (CBF) was measured in CP-patients having a normal CT-scan. The aim was to correlate the CBF changes with the clinical and the etiologic findings. CBF was measured by xenon-133 inhalation and single photon emission computer tomography. The mean CBF value in 20 CP-patients, age 6-19 years, was 67 +/- 11 (1 SD) ml/100g/min, the same value as found in the 9 normal children. However, 16 of the 20 CP-patients had focal hypoperfused areas on the tomographic flow map. In the preterm infants (n = 7) the hypoperfused areas were mainly located in the posterior watershed areas, often in one hemisphere only. In the term infants (n = 13) both asymmetrical and symmetrical hypoperfused areas were observed in the anterior and posterior watershed areas. In addition, several children had larger low flow areas in the frontal and fronto-parietal lobes. In both groups, a relatively poor concordance was observed between the clinical findings and the expected location of the low flow area.
%0 Journal Article
%1 Taudorf1989
%A Taudorf, K.
%A Vorstrup, S.
%D 1989
%J Neuropediatrics
%K Adolescent; Adult; Blood Flow Velocity; Cerebral Palsy; Cerebrovascular Circulation; Child; Female; Humans; Image Processing, Computer-Assisted; Infant, Newborn; Premature; Male; Tomography, X-Ray Computed
%N 1
%P 33--40
%T Cerebral blood flow abnormalities in cerebral palsied children with a normal CT scan.
%V 20
%X Cerebral palsy (CP) is often a consequence of a hypoxic-ischemic encephalopathy and/or intracerebral hemorrhage secondary to pre- and peri-natal asphyxia. Hypodense lesions on the CT-scan are found in about 70 to 80\% of CP-patients. In the present study, regional cerebral blood flow (CBF) was measured in CP-patients having a normal CT-scan. The aim was to correlate the CBF changes with the clinical and the etiologic findings. CBF was measured by xenon-133 inhalation and single photon emission computer tomography. The mean CBF value in 20 CP-patients, age 6-19 years, was 67 +/- 11 (1 SD) ml/100g/min, the same value as found in the 9 normal children. However, 16 of the 20 CP-patients had focal hypoperfused areas on the tomographic flow map. In the preterm infants (n = 7) the hypoperfused areas were mainly located in the posterior watershed areas, often in one hemisphere only. In the term infants (n = 13) both asymmetrical and symmetrical hypoperfused areas were observed in the anterior and posterior watershed areas. In addition, several children had larger low flow areas in the frontal and fronto-parietal lobes. In both groups, a relatively poor concordance was observed between the clinical findings and the expected location of the low flow area.
@article{Taudorf1989,
abstract = {Cerebral palsy (CP) is often a consequence of a hypoxic-ischemic encephalopathy and/or intracerebral hemorrhage secondary to pre- and peri-natal asphyxia. Hypodense lesions on the CT-scan are found in about 70 to 80\% of CP-patients. In the present study, regional cerebral blood flow (CBF) was measured in CP-patients having a normal CT-scan. The aim was to correlate the CBF changes with the clinical and the etiologic findings. CBF was measured by xenon-133 inhalation and single photon emission computer tomography. The mean CBF value in 20 CP-patients, age 6-19 years, was 67 +/- 11 (1 SD) ml/100g/min, the same value as found in the 9 normal children. However, 16 of the 20 CP-patients had focal hypoperfused areas on the tomographic flow map. In the preterm infants (n = 7) the hypoperfused areas were mainly located in the posterior watershed areas, often in one hemisphere only. In the term infants (n = 13) both asymmetrical and symmetrical hypoperfused areas were observed in the anterior and posterior watershed areas. In addition, several children had larger low flow areas in the frontal and fronto-parietal lobes. In both groups, a relatively poor concordance was observed between the clinical findings and the expected location of the low flow area.},
added-at = {2014-07-19T21:42:33.000+0200},
author = {Taudorf, K. and Vorstrup, S.},
biburl = {https://www.bibsonomy.org/bibtex/29375109b36aaeb4c1313ed12438e30eb/ar0berts},
groups = {public},
interhash = {a4d3d886b8345295faaf2bcf516e3ee8},
intrahash = {9375109b36aaeb4c1313ed12438e30eb},
journal = {Neuropediatrics},
keywords = {Adolescent; Adult; Blood Flow Velocity; Cerebral Palsy; Cerebrovascular Circulation; Child; Female; Humans; Image Processing, Computer-Assisted; Infant, Newborn; Premature; Male; Tomography, X-Ray Computed},
month = Feb,
number = 1,
pages = {33--40},
pmid = {2716964},
timestamp = {2014-07-19T21:45:47.000+0200},
title = {Cerebral blood flow abnormalities in cerebral palsied children with a normal CT scan.},
username = {ar0berts},
volume = 20,
year = 1989
}