Temporal perception is fundamental to environmental adaptation in
humans and other animals. To deal with timing and time perception,
organisms have developed multiple systems that are active over a
broad range of order of magnitude, the most important being circadian
timing, interval timing and millisecond timing. The circadian pacemaker
is located in the suprachiasmatic nuclei (SCN) of the hypothalamus,
and is driven by a self-sustaining oscillator with a period close
to 24 h. Time estimation in the second-to-minutes range – known as
interval timing – involves the interaction of the basal ganglia and
the prefrontal cortex. In this work we tested the hypothesis that
interval timing in mice is sensitive to circadian modulations. Animals
were trained following the peak-interval (PI) procedure. Results
show significant differences in the estimation of 24-second intervals
at different times of day, with a higher accuracy in the group trained
at night, which were maintained under constant dark (DD) conditions.
Interval timing was also studied in animals under constant light
(LL) conditions, which abolish circadian rhythmicity. Mice under
LL conditions were unable to acquire temporal control in the peak
interval procedure. Moreover, short time estimation in animals subjected
to circadian desynchronizations (modeling jet lag-like situations)
was also affected. Taken together, our results indicate that short-time
estimation is modulated by the circadian clock. ⺠Interval timing
in mice is modulated by the circadian system. ⺠Interval timing
accuracy is better at night, both under LD and DD conditions. âº
Interval timing performance is severely decreased under LL conditions.
⺠Interval timing performance is affected by circadian desynchronization.
%0 Journal Article
%1 Agostino2011
%A Agostino, Patricia
%A do Nascimento, Micaela
%A Bussi, Ivana
%A Eguía, Manuel
%A Golombek, Diego
%D 2011
%J Brain Research
%K chronobiology, timing
%P 154--163
%T Circadian modulation of interval timing in mice
%U http://dx.doi.org/10.1016/j.brainres.2010.11.029
%V 1370
%X Temporal perception is fundamental to environmental adaptation in
humans and other animals. To deal with timing and time perception,
organisms have developed multiple systems that are active over a
broad range of order of magnitude, the most important being circadian
timing, interval timing and millisecond timing. The circadian pacemaker
is located in the suprachiasmatic nuclei (SCN) of the hypothalamus,
and is driven by a self-sustaining oscillator with a period close
to 24 h. Time estimation in the second-to-minutes range – known as
interval timing – involves the interaction of the basal ganglia and
the prefrontal cortex. In this work we tested the hypothesis that
interval timing in mice is sensitive to circadian modulations. Animals
were trained following the peak-interval (PI) procedure. Results
show significant differences in the estimation of 24-second intervals
at different times of day, with a higher accuracy in the group trained
at night, which were maintained under constant dark (DD) conditions.
Interval timing was also studied in animals under constant light
(LL) conditions, which abolish circadian rhythmicity. Mice under
LL conditions were unable to acquire temporal control in the peak
interval procedure. Moreover, short time estimation in animals subjected
to circadian desynchronizations (modeling jet lag-like situations)
was also affected. Taken together, our results indicate that short-time
estimation is modulated by the circadian clock. ⺠Interval timing
in mice is modulated by the circadian system. ⺠Interval timing
accuracy is better at night, both under LD and DD conditions. âº
Interval timing performance is severely decreased under LL conditions.
⺠Interval timing performance is affected by circadian desynchronization.
@article{Agostino2011,
__markedentry = {[freesurfer:6]},
abstract = {Temporal perception is fundamental to environmental adaptation in
humans and other animals. To deal with timing and time perception,
organisms have developed multiple systems that are active over a
broad range of order of magnitude, the most important being circadian
timing, interval timing and millisecond timing. The circadian pacemaker
is located in the suprachiasmatic nuclei (SCN) of the hypothalamus,
and is driven by a self-sustaining oscillator with a period close
to 24 h. Time estimation in the second-to-minutes range – known as
interval timing – involves the interaction of the basal ganglia and
the prefrontal cortex. In this work we tested the hypothesis that
interval timing in mice is sensitive to circadian modulations. Animals
were trained following the peak-interval (PI) procedure. Results
show significant differences in the estimation of 24-second intervals
at different times of day, with a higher accuracy in the group trained
at night, which were maintained under constant dark (DD) conditions.
Interval timing was also studied in animals under constant light
(LL) conditions, which abolish circadian rhythmicity. Mice under
LL conditions were unable to acquire temporal control in the peak
interval procedure. Moreover, short time estimation in animals subjected
to circadian desynchronizations (modeling jet lag-like situations)
was also affected. Taken together, our results indicate that short-time
estimation is modulated by the circadian clock. ⺠Interval timing
in mice is modulated by the circadian system. ⺠Interval timing
accuracy is better at night, both under LD and DD conditions. âº
Interval timing performance is severely decreased under LL conditions.
⺠Interval timing performance is affected by circadian desynchronization.},
added-at = {2012-02-24T14:11:06.000+0100},
author = {Agostino, Patricia and do Nascimento, Micaela and Bussi, Ivana and Eguía, Manuel and Golombek, Diego},
biburl = {https://www.bibsonomy.org/bibtex/29b22970f71131668a214926e318c09c7/jakspa},
interhash = {7f186b0974d58588c2d2e9b2ff9a4cd9},
intrahash = {9b22970f71131668a214926e318c09c7},
issn = {00068993},
journal = {Brain Research},
keywords = {chronobiology, timing},
month = jan,
owner = {freesurfer},
pages = {154--163},
refid = {citeulike:8264834},
timestamp = {2012-02-24T14:11:06.000+0100},
title = {Circadian modulation of interval timing in mice},
url = {http://dx.doi.org/10.1016/j.brainres.2010.11.029},
volume = 1370,
year = 2011
}