%0 Journal Article %1 Graeser.2009b %A Graeser, Monika K. %A Engel, Christoph %A Rhiem, Kerstin %A Gadzicki, Dorothea %A Bick, Ulrich %A Kast, Karin %A Froster, Ursula G. %A Schlehe, Bettina %A Bechtold, Astrid %A Arnold, Norbert %A Preisler-Adams, Sabine %A Nestle-Kraemling, Carolin %A Zaino, Mohammad %A Loeffler, Markus %A Kiechle, Marion %A Meindl, Alfons %A Varga, Dominic %A Schmutzler, Rita K. %D 2009 %J Journal of clinical oncology : official journal of the American Society of Clinical Oncology %K Adult Age_Factors Apoptosis_Regulatory_Proteins BRCA1_Protein/genetics BRCA2_Protein/genetics Breast_Neoplasms/genetics/pathology/therapy Female Gene_Expression_Regulation,_Neoplastic Genetic_Predisposition_to_Disease Germany Humans Kaplan-Meier_Estimate Middle_Aged Mutation Neoplasms,_Second_Primary Pedigree Proportional_Hazards_Models Retrospective_Studies Risk_Assessment Risk_Factors Time_Factors Treatment_Outcome %N 35 %P 5887–5892 %T Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers %V 27 %X PURPOSE\r\nTo estimate the risk for contralateral breast cancer in members of BRCA1- and BRCA2-positive families and to determine predictive risk factors.\r\nPATIENTS AND METHODS\r\nA retrospective, multicenter, cohort study was performed from 1996 until 2008 and comprised 2,020 women with unilateral breast cancer (index patients, n = 978; relatives, n = 1.42) from 978 families who had a BRCA1 or BRCA2 mutation. Cox regression analysis was applied to assess the association of age at first breast cancer with time from first to contralateral breast cancer, stratified by the affected BRCA gene.\r\nRESULTS\r\nThe cumulative risk for contralateral breast cancer 25 years after first breast cancer was 47.4\% (95\% CI, 38.8\% to 56.0\%) for patients from families with BRCA1 or BRCA2 mutations. Members of families with BRCA1 mutations had a 1.6-fold (95\% CI, 1.2-fold to 2.3-fold) higher risk of contralateral breast cancer than members of families with BRCA2 mutations. Younger age at first breast cancer was associated with a significantly higher risk of contralateral breast cancer in patients with BRCA1 mutation, and a trend was observed in patients with BRCA2 mutation. After 25 years, 62.9\% (95\% CI, 50.4\% to 75.4\%) of patients with BRCA1 mutation who were younger than 40 years of age at first breast cancer developed contralateral breast cancer, compared with only 19.6\% (95\% CI, 5.3\% to 33.9\%) of those who were older than 50 years of age at first breast cancer.\r\nCONCLUSION\r\nContralateral breast cancer risk depends on age at first breast cancer and on the affected BRCA gene, and this risk should be considered in treatment planning.

@article{Graeser.2009b, abstract = {PURPOSE\r\nTo estimate the risk for contralateral breast cancer in members of BRCA1- and BRCA2-positive families and to determine predictive risk factors.\r\nPATIENTS AND METHODS\r\nA retrospective, multicenter, cohort study was performed from 1996 until 2008 and comprised 2,020 women with unilateral breast cancer (index patients, n = 978; relatives, n = 1.42) from 978 families who had a BRCA1 or BRCA2 mutation. Cox regression analysis was applied to assess the association of age at first breast cancer with time from first to contralateral breast cancer, stratified by the affected BRCA gene.\r\nRESULTS\r\nThe cumulative risk for contralateral breast cancer 25 years after first breast cancer was 47.4\% (95\% CI, 38.8\% to 56.0\%) for patients from families with BRCA1 or BRCA2 mutations. Members of families with BRCA1 mutations had a 1.6-fold (95\% CI, 1.2-fold to 2.3-fold) higher risk of contralateral breast cancer than members of families with BRCA2 mutations. Younger age at first breast cancer was associated with a significantly higher risk of contralateral breast cancer in patients with BRCA1 mutation, and a trend was observed in patients with BRCA2 mutation. After 25 years, 62.9\% (95\% CI, 50.4\% to 75.4\%) of patients with BRCA1 mutation who were younger than 40 years of age at first breast cancer developed contralateral breast cancer, compared with only 19.6\% (95\% CI, 5.3\% to 33.9\%) of those who were older than 50 years of age at first breast cancer.\r\nCONCLUSION\r\nContralateral breast cancer risk depends on age at first breast cancer and on the affected BRCA gene, and this risk should be considered in treatment planning.}, added-at = {2014-10-15T15:03:50.000+0200}, author = {Graeser, Monika K. and Engel, Christoph and Rhiem, Kerstin and Gadzicki, Dorothea and Bick, Ulrich and Kast, Karin and Froster, Ursula G. and Schlehe, Bettina and Bechtold, Astrid and Arnold, Norbert and Preisler-Adams, Sabine and Nestle-Kraemling, Carolin and Zaino, Mohammad and Loeffler, Markus and Kiechle, Marion and Meindl, Alfons and Varga, Dominic and Schmutzler, Rita K.}, biburl = {https://www.bibsonomy.org/bibtex/2a0a61c9ea449076076c2abe582418a68/drtester}, interhash = {f1e495ab2fa889064a5ee36f1aaa0c96}, intrahash = {a0a61c9ea449076076c2abe582418a68}, journal = {Journal of clinical oncology : official journal of the American Society of Clinical Oncology}, keywords = {Adult Age_Factors Apoptosis_Regulatory_Proteins BRCA1_Protein/genetics BRCA2_Protein/genetics Breast_Neoplasms/genetics/pathology/therapy Female Gene_Expression_Regulation,_Neoplastic Genetic_Predisposition_to_Disease Germany Humans Kaplan-Meier_Estimate Middle_Aged Mutation Neoplasms,_Second_Primary Pedigree Proportional_Hazards_Models Retrospective_Studies Risk_Assessment Risk_Factors Time_Factors Treatment_Outcome}, number = 35, pages = {5887–5892}, timestamp = {2014-10-15T15:03:50.000+0200}, title = {Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers}, volume = 27, year = 2009 }