Allium sativum aqueous extract prevents potassium dichromate-induced nephrotoxicity and lipid oxidation in rats │El extracto acuoso de Allium sativum previene la nefrotoxicidad y la oxidación lipídica inducida por dicromato de potasio en ratas
Context: The potassium dichromate (K2Cr2O7) induces nephrotoxicity by oxidative stress mechanisms.
Aims: To study the potential protection of an aqueous extract of Allium sativum against the K2Cr2O7-induced nephrotoxicity and lipid oxidation in rats.
Methods: Twenty four hours after treatment, biomarkers such as proteinuria, creatinine clearance, malondialdehyde production, specific enzyme activity of gamma glutamyl transpeptidase and alanine aminopeptidase, and renal clearance of para-aminohippuric acid and inulin were measured.
Results: The K2Cr2O7 caused significant renal dysfunction, but A. sativum extract prevented this condition by improving all measured biomarkers.
Conclusions: A single injection of K2Cr2O7 induced nephrotoxicity in rats, but the supply of an Allium sativum aqueous extract prevented the disorders caused by this metal.
%0 Journal Article
%1 becerratorres2014allium
%A Becerra-Torres, Sergio L.
%A Soria-Fregozo, César
%A Jaramillo-Juárez, Fernando
%A Moreno-Hernández-Duque, José L.
%D 2014
%E JPPRes,
%J Journal of Pharmacy & Pharmacognosy Research
%K aclaramiento creatinina creatinine extracto-de-ajo garlic-extract inulin inulina malondialdehyde malondialdehído proteinuria renal-clearance
%N 2
%P 45-52
%T Allium sativum aqueous extract prevents potassium dichromate-induced nephrotoxicity and lipid oxidation in rats │El extracto acuoso de Allium sativum previene la nefrotoxicidad y la oxidación lipídica inducida por dicromato de potasio en ratas
%U http://jppres.com/jppres/pdf/vol2/jppres14.020_2.2.45.pdf
%V 2
%X Context: The potassium dichromate (K2Cr2O7) induces nephrotoxicity by oxidative stress mechanisms.
Aims: To study the potential protection of an aqueous extract of Allium sativum against the K2Cr2O7-induced nephrotoxicity and lipid oxidation in rats.
Methods: Twenty four hours after treatment, biomarkers such as proteinuria, creatinine clearance, malondialdehyde production, specific enzyme activity of gamma glutamyl transpeptidase and alanine aminopeptidase, and renal clearance of para-aminohippuric acid and inulin were measured.
Results: The K2Cr2O7 caused significant renal dysfunction, but A. sativum extract prevented this condition by improving all measured biomarkers.
Conclusions: A single injection of K2Cr2O7 induced nephrotoxicity in rats, but the supply of an Allium sativum aqueous extract prevented the disorders caused by this metal.
@article{becerratorres2014allium,
abstract = {Context: The potassium dichromate (K2Cr2O7) induces nephrotoxicity by oxidative stress mechanisms.
Aims: To study the potential protection of an aqueous extract of Allium sativum against the K2Cr2O7-induced nephrotoxicity and lipid oxidation in rats.
Methods: Twenty four hours after treatment, biomarkers such as proteinuria, creatinine clearance, malondialdehyde production, specific enzyme activity of gamma glutamyl transpeptidase and alanine aminopeptidase, and renal clearance of para-aminohippuric acid and inulin were measured.
Results: The K2Cr2O7 caused significant renal dysfunction, but A. sativum extract prevented this condition by improving all measured biomarkers.
Conclusions: A single injection of K2Cr2O7 induced nephrotoxicity in rats, but the supply of an Allium sativum aqueous extract prevented the disorders caused by this metal. },
added-at = {2014-04-27T09:21:25.000+0200},
author = {Becerra-Torres, Sergio L. and Soria-Fregozo, César and Jaramillo-Juárez, Fernando and Moreno-Hernández-Duque, José L.},
biburl = {https://www.bibsonomy.org/bibtex/2a5746732a02f936b1259db5e67f59d62/jppres},
editor = {JPPRes},
interhash = {4a785f480bb5eb76d67a410b286bce6f},
intrahash = {a5746732a02f936b1259db5e67f59d62},
journal = {Journal of Pharmacy & Pharmacognosy Research},
keywords = {aclaramiento creatinina creatinine extracto-de-ajo garlic-extract inulin inulina malondialdehyde malondialdehído proteinuria renal-clearance},
month = {April},
number = 2,
pages = {45-52},
timestamp = {2014-04-27T09:22:51.000+0200},
title = {Allium sativum aqueous extract prevents potassium dichromate-induced nephrotoxicity and lipid oxidation in rats │[El extracto acuoso de Allium sativum previene la nefrotoxicidad y la oxidación lipídica inducida por dicromato de potasio en ratas]},
url = {http://jppres.com/jppres/pdf/vol2/jppres14.020_2.2.45.pdf},
volume = 2,
year = 2014
}