%0 Journal Article %1 myers2005finescale %A Myers, Simon %A Bottolo, Leonardo %A Freeman, Colin %A McVean, Gil %A Donnelly, Peter %D 2005 %J Science %K human_genome population_genomics recombination %N 5746 %P 321-324 %R 10.1126/science.1117196 %T A Fine-Scale Map of Recombination Rates and Hotspots Across the Human Genome %U http://www.sciencemag.org/content/310/5746/321.abstract %V 310 %X Genetic maps, which document the way in which recombination rates vary over a genome, are an essential tool for many genetic analyses. We present a high-resolution genetic map of the human genome, based on statistical analyses of genetic variation data, and identify more than 25,000 recombination hotspots, together with motifs and sequence contexts that play a role in hotspot activity. Differences between the behavior of recombination rates over large (megabase) and small (kilobase) scales lead us to suggest a two-stage model for recombination in which hotspots are stochastic features, within a framework in which large-scale rates are constrained.

@article{myers2005finescale, abstract = {Genetic maps, which document the way in which recombination rates vary over a genome, are an essential tool for many genetic analyses. We present a high-resolution genetic map of the human genome, based on statistical analyses of genetic variation data, and identify more than 25,000 recombination hotspots, together with motifs and sequence contexts that play a role in hotspot activity. Differences between the behavior of recombination rates over large (megabase) and small (kilobase) scales lead us to suggest a two-stage model for recombination in which hotspots are stochastic features, within a framework in which large-scale rates are constrained.}, added-at = {2011-11-18T03:48:32.000+0100}, author = {Myers, Simon and Bottolo, Leonardo and Freeman, Colin and McVean, Gil and Donnelly, Peter}, biburl = {https://www.bibsonomy.org/bibtex/2aef4e5b16151eab450f4cd55d8d08c94/peter.ralph}, doi = {10.1126/science.1117196}, eprint = {http://www.sciencemag.org/content/310/5746/321.full.pdf}, interhash = {ff2d00ef8a875895b9d1b0a6320bc9b8}, intrahash = {aef4e5b16151eab450f4cd55d8d08c94}, journal = {Science}, keywords = {human_genome population_genomics recombination}, number = 5746, pages = {321-324}, timestamp = {2011-11-18T03:48:32.000+0100}, title = {A Fine-Scale Map of Recombination Rates and Hotspots Across the Human Genome}, url = {http://www.sciencemag.org/content/310/5746/321.abstract}, volume = 310, year = 2005 }