%0 Journal Article %1 noauthororeditor %A Singh, M %A Lennon, RJ %D 2020 %J Eur Heart J Qual Care Clin Outcomes %K mi&qol %P qcaa065 %R 10.1093/ehjqcco/qcaa065 %T Poor quality of life in patients with and without frailty: Co-prevalence and prognostic implications in patients undergoing percutaneous coronary interventions and cardiac catheterization %U https://academic.oup.com/ehjqcco/advance-article-abstract/doi/10.1093/ehjqcco/qcaa065/5895308#annotations:GUA67BZtEeuPOJ8PxKmmXw %X Background: We hypothesize that poor QOL is highly prevalent in frail older adults and is associated with worse prognosis. Methods and results: Predismissal standardized tests for frailty and QOL were prospectively administered to patients included in 2 cohorts. In cohort 1, 629 patients ≥ 65 years who underwent percutaneous coronary intervention (PCI) from 2005-2008, frailty (Fried criteria) and QOL SF-36 and Seattle Angina Questionnaires (SAQ) were ascertained. Cohort 2 included 921 patients ≥55 years who underwent cardiac catheterization (535 had PCI) from 2014-18 and frailty was determined by Rockwood criteria and QOL by single-item, self-reported health questionnaire. In cohort 1, 19% were frail and 20% patients in cohort 2 were frail with a frailty index>0.30. The median SAQ for physical limitation (58.9 vs. 82.2, p < 0.001); physical (29.5 vs. 43.9, p < 0.001) and mental (49.2 vs. 57.4, p < 0.001) component scores of SF-36 in cohort 1 were lower and self-rating of fair/poor health (56% vs 18%, p < 0.001) in cohort 2 was significantly higher in frail patients. As compared to patients without frailty, frail patients were 5 times more likely (59% vs. 11%, p < 0.001) in cohort 1 and 7 times more likely (56% vs. 8%) in cohort 2 to be classified with poor QOL. Age- and gender-adjusted three year all-cause death and death or myocardial infarction (MI) was significantly higher for patients undergoing PCI with frailty; HR (95% CI) death, 4.20 (2.63, 6.68, p < 0.001) and death or MI HR 2.72 (1.91, 3.87, p < 0.001) and with poor QOL HR death 2.47 (1.59, 3.84, p < 0.001) and death or MI 1.61 (1.16, 2.24, p < 0.001). There was no significant interaction between frailty and QOL (p = 0.64) and only modest attenuation was observed when considered together indicating their independent prognostic influence. Conclusions: In elderly patients undergoing cardiac catheterization or PCI, poor QOL is seen more frequently in frail patients. Both frailty and poor QOL had significant and independent association with long-term survival.

@article{noauthororeditor, abstract = {Background: We hypothesize that poor QOL is highly prevalent in frail older adults and is associated with worse prognosis. Methods and results: Predismissal standardized tests for frailty and QOL were prospectively administered to patients included in 2 cohorts. In cohort 1, 629 patients ≥ 65 years who underwent percutaneous coronary intervention (PCI) from 2005-2008, frailty (Fried criteria) and QOL [SF-36 and Seattle Angina Questionnaires (SAQ)] were ascertained. Cohort 2 included 921 patients ≥55 years who underwent cardiac catheterization (535 had PCI) from 2014-18 and frailty was determined by Rockwood criteria and QOL by single-item, self-reported health questionnaire. In cohort 1, 19% were frail and 20% patients in cohort 2 were frail with a frailty index>0.30. The median SAQ for physical limitation (58.9 vs. 82.2, p < 0.001); physical (29.5 vs. 43.9, p < 0.001) and mental (49.2 vs. 57.4, p < 0.001) component scores of SF-36 in cohort 1 were lower and self-rating of fair/poor health (56% vs 18%, p < 0.001) in cohort 2 was significantly higher in frail patients. As compared to patients without frailty, frail patients were 5 times more likely (59% vs. 11%, p < 0.001) in cohort 1 and 7 times more likely (56% vs. 8%) in cohort 2 to be classified with poor QOL. Age- and gender-adjusted three year all-cause death and death or myocardial infarction (MI) was significantly higher for patients undergoing PCI with frailty; [HR (95% CI) death, 4.20 (2.63, 6.68, p < 0.001) and death or MI HR 2.72 (1.91, 3.87, p < 0.001)] and with poor QOL [HR death 2.47 (1.59, 3.84, p < 0.001) and death or MI 1.61 (1.16, 2.24, p < 0.001). There was no significant interaction between frailty and QOL (p = 0.64) and only modest attenuation was observed when considered together indicating their independent prognostic influence. Conclusions: In elderly patients undergoing cardiac catheterization or PCI, poor QOL is seen more frequently in frail patients. Both frailty and poor QOL had significant and independent association with long-term survival.}, added-at = {2020-11-03T01:23:10.000+0100}, author = {Singh, M and Lennon, RJ}, biburl = {https://www.bibsonomy.org/bibtex/2b3a32051a49c490346bf312e3f47e91e/rodrigogopar}, description = {Poor quality of life in patients with and without frailty: Co-prevalence and prognostic implications in patients undergoing percutaneous coronary interventions and cardiac catheterization | European Heart Journal - Quality of Care and Clinical Outcomes | Oxford Academic}, doi = {10.1093/ehjqcco/qcaa065}, interhash = {ed983c8c8a7220f31961e8f4dcf89288}, intrahash = {b3a32051a49c490346bf312e3f47e91e}, journal = {Eur Heart J Qual Care Clin Outcomes}, keywords = {mi&qol}, pages = {qcaa065}, timestamp = {2020-11-03T01:23:10.000+0100}, title = {Poor quality of life in patients with and without frailty: Co-prevalence and prognostic implications in patients undergoing percutaneous coronary interventions and cardiac catheterization}, url = {https://academic.oup.com/ehjqcco/advance-article-abstract/doi/10.1093/ehjqcco/qcaa065/5895308#annotations:GUA67BZtEeuPOJ8PxKmmXw}, year = 2020 }