Robustness is the invariance of phenotypes in the face of perturbation. The robustness of phenotypes appears at various levels of biological organization, including gene expression, protein folding, metabolic flux, physiological homeostasis, development, and even organismal fitness. The mechanisms underlying robustness are diverse, ranging from thermodynamic stability at the RNA and protein level to behavior at the organismal level. Phenotypes can be robust either against heritable perturbations (e.g., mutations) or nonheritable perturbations (e.g., the weather). Here we primarily focus on the first kind of robustness--genetic robustness--and survey three growing avenues of research: (1) measuring genetic robustness in nature and in the laboratory; (2) understanding the evolution of genetic robustness: and (3) exploring the implications of genetic robustness for future evolution.
Description
Perspective: Evolution and detection of genetic ro...[Evolution. 2003] - PubMed Result
%0 Journal Article
%1 deVisser:2003:Evolution:14575319
%A de Visser, J A
%A Hermisson, J
%A Wagner, G P
%A Meyers, L Ancel
%A Bagheri-Chaichian, H
%A Blanchard, J L
%A Chao, L
%A Cheverud, J M
%A Elena, S F
%A Fontana, W
%A Gibson, G
%A Hansen, T F
%A Krakauer, D
%A Lewontin, R C
%A Ofria, C
%A Rice, S H
%A von Dassow, G
%A Wagner, A
%A Whitlock, M C
%D 2003
%J Evolution
%K dl evolution imported robustness
%N 9
%P 1959-1972
%T Perspective: Evolution and detection of genetic robustness
%U http://www.ncbi.nlm.nih.gov/pubmed/14575319
%V 57
%X Robustness is the invariance of phenotypes in the face of perturbation. The robustness of phenotypes appears at various levels of biological organization, including gene expression, protein folding, metabolic flux, physiological homeostasis, development, and even organismal fitness. The mechanisms underlying robustness are diverse, ranging from thermodynamic stability at the RNA and protein level to behavior at the organismal level. Phenotypes can be robust either against heritable perturbations (e.g., mutations) or nonheritable perturbations (e.g., the weather). Here we primarily focus on the first kind of robustness--genetic robustness--and survey three growing avenues of research: (1) measuring genetic robustness in nature and in the laboratory; (2) understanding the evolution of genetic robustness: and (3) exploring the implications of genetic robustness for future evolution.
@article{deVisser:2003:Evolution:14575319,
abstract = {Robustness is the invariance of phenotypes in the face of perturbation. The robustness of phenotypes appears at various levels of biological organization, including gene expression, protein folding, metabolic flux, physiological homeostasis, development, and even organismal fitness. The mechanisms underlying robustness are diverse, ranging from thermodynamic stability at the RNA and protein level to behavior at the organismal level. Phenotypes can be robust either against heritable perturbations (e.g., mutations) or nonheritable perturbations (e.g., the weather). Here we primarily focus on the first kind of robustness--genetic robustness--and survey three growing avenues of research: (1) measuring genetic robustness in nature and in the laboratory; (2) understanding the evolution of genetic robustness: and (3) exploring the implications of genetic robustness for future evolution.},
added-at = {2009-09-16T04:21:11.000+0200},
author = {de Visser, J A and Hermisson, J and Wagner, G P and Meyers, L Ancel and Bagheri-Chaichian, H and Blanchard, J L and Chao, L and Cheverud, J M and Elena, S F and Fontana, W and Gibson, G and Hansen, T F and Krakauer, D and Lewontin, R C and Ofria, C and Rice, S H and von Dassow, G and Wagner, A and Whitlock, M C},
biburl = {https://www.bibsonomy.org/bibtex/2b3ef6553329d18d2f9f805755f48cf49/ebo},
description = {Perspective: Evolution and detection of genetic ro...[Evolution. 2003] - PubMed Result},
interhash = {b79c5b0eefd1978cfe8e71f1933413a2},
intrahash = {b3ef6553329d18d2f9f805755f48cf49},
journal = {Evolution},
keywords = {dl evolution imported robustness},
month = Sep,
number = 9,
pages = {1959-1972},
pmid = {14575319},
timestamp = {2009-09-16T04:28:30.000+0200},
title = {Perspective: Evolution and detection of genetic robustness},
url = {http://www.ncbi.nlm.nih.gov/pubmed/14575319},
volume = 57,
year = 2003
}