Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic glioma driving alterations and suboptimal disease classification. We defined the complete set of genes associated with 1,122 diffuse grade II-III-IV gliomas from The Cancer Genome Atlas and used molecular profiles to improve disease classification, identify molecular correlations, and provide insights into the progression from low- to high-grade disease. Whole-genome sequencing data analysis determined that ATRX but not TERT promoter mutations are associated with increased telomere length. Recent advances in glioma classification based on IDH mutation and 1p/19q co-deletion status were recapitulated through analysis of DNA methylation profiles, which identified clinically relevant molecular subsets. A subtype of IDH mutant glioma was associated with DNA demethylation and poor outcome; a group of IDH-wild-type diffuse glioma showed molecular similarity to pilocytic astrocytoma and relatively favorable survival. Understanding of cohesive disease groups may aid improved clinical outcomes.
Description
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma. - PubMed - NCBI
%0 Journal Article
%1 ceccarelli2016molecular
%A Ceccarelli, M
%A Barthel, F P
%A Malta, T M
%A Sabedot, T S
%A Salama, S R
%A Murray, B A
%A Morozova, O
%A Newton, Y
%A Radenbaugh, A
%A Pagnotta, S M
%A Anjum, S
%A Wang, J
%A Manyam, G
%A Zoppoli, P
%A Ling, S
%A Rao, A A
%A Grifford, M
%A Cherniack, A D
%A Zhang, H
%A Poisson, L
%A Carlotti, C G
%A Tirapelli, D P
%A Rao, A
%A Mikkelsen, T
%A Lau, C C
%A Yung, W K
%A Rabadan, R
%A Huse, J
%A Brat, D J
%A Lehman, N L
%A Barnholtz-Sloan, J S
%A Zheng, S
%A Hess, K
%A Rao, G
%A Meyerson, M
%A Beroukhim, R
%A Cooper, L
%A Akbani, R
%A Wrensch, M
%A Haussler, D
%A Aldape, K D
%A Laird, P W
%A Gutmann, D H
%A TCGA Research Network,
%A Noushmehr, H
%A Iavarone, A
%A Verhaak, R G
%D 2016
%J Cell
%K MUSTREAD fulltext glioma pathway profiling tcga
%N 3
%P 550-563
%R 10.1016/j.cell.2015.12.028
%T Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
%U https://www.ncbi.nlm.nih.gov/pubmed/26824661
%V 164
%X Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic glioma driving alterations and suboptimal disease classification. We defined the complete set of genes associated with 1,122 diffuse grade II-III-IV gliomas from The Cancer Genome Atlas and used molecular profiles to improve disease classification, identify molecular correlations, and provide insights into the progression from low- to high-grade disease. Whole-genome sequencing data analysis determined that ATRX but not TERT promoter mutations are associated with increased telomere length. Recent advances in glioma classification based on IDH mutation and 1p/19q co-deletion status were recapitulated through analysis of DNA methylation profiles, which identified clinically relevant molecular subsets. A subtype of IDH mutant glioma was associated with DNA demethylation and poor outcome; a group of IDH-wild-type diffuse glioma showed molecular similarity to pilocytic astrocytoma and relatively favorable survival. Understanding of cohesive disease groups may aid improved clinical outcomes.
@article{ceccarelli2016molecular,
abstract = {Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic glioma driving alterations and suboptimal disease classification. We defined the complete set of genes associated with 1,122 diffuse grade II-III-IV gliomas from The Cancer Genome Atlas and used molecular profiles to improve disease classification, identify molecular correlations, and provide insights into the progression from low- to high-grade disease. Whole-genome sequencing data analysis determined that ATRX but not TERT promoter mutations are associated with increased telomere length. Recent advances in glioma classification based on IDH mutation and 1p/19q co-deletion status were recapitulated through analysis of DNA methylation profiles, which identified clinically relevant molecular subsets. A subtype of IDH mutant glioma was associated with DNA demethylation and poor outcome; a group of IDH-wild-type diffuse glioma showed molecular similarity to pilocytic astrocytoma and relatively favorable survival. Understanding of cohesive disease groups may aid improved clinical outcomes.},
added-at = {2017-05-30T17:25:46.000+0200},
author = {Ceccarelli, M and Barthel, F P and Malta, T M and Sabedot, T S and Salama, S R and Murray, B A and Morozova, O and Newton, Y and Radenbaugh, A and Pagnotta, S M and Anjum, S and Wang, J and Manyam, G and Zoppoli, P and Ling, S and Rao, A A and Grifford, M and Cherniack, A D and Zhang, H and Poisson, L and Carlotti, C G and Tirapelli, D P and Rao, A and Mikkelsen, T and Lau, C C and Yung, W K and Rabadan, R and Huse, J and Brat, D J and Lehman, N L and Barnholtz-Sloan, J S and Zheng, S and Hess, K and Rao, G and Meyerson, M and Beroukhim, R and Cooper, L and Akbani, R and Wrensch, M and Haussler, D and Aldape, K D and Laird, P W and Gutmann, D H and {TCGA Research Network} and Noushmehr, H and Iavarone, A and Verhaak, R G},
biburl = {https://www.bibsonomy.org/bibtex/2b59320daa15ba2d4433b28a6599a41b9/marcsaric},
description = {Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma. - PubMed - NCBI},
doi = {10.1016/j.cell.2015.12.028},
interhash = {fa7a29af77b91a3911c994d7148e2355},
intrahash = {b59320daa15ba2d4433b28a6599a41b9},
journal = {Cell},
keywords = {MUSTREAD fulltext glioma pathway profiling tcga},
month = jan,
number = 3,
pages = {550-563},
pmid = {26824661},
timestamp = {2017-05-30T17:25:46.000+0200},
title = {Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma},
url = {https://www.ncbi.nlm.nih.gov/pubmed/26824661},
volume = 164,
year = 2016
}