We have created genetically altered mice to investigate how expression
of the Na$^+$-Ca$^2+$ exchange protein alters excitation-contraction
(E-C) coupling. Whereas low levels of exchanger overexpression have
minimal effects on E-C coupling properties, high levels of overexpression
in homozygous animals results in susceptibility to hypertrophy and
heart failure, along with a significant reduction in E-C coupling
gain. While global knockout of the exchanger in mice is embryonic-lethal,
conditional knockout mice live to adulthood. Cardiac function is
surprisingly normal in seven-week-old mice, but E-C coupling gain
is apparently increased. Thus, genetic modification of exchanger
expression has a major influence on E-C coupling.
%0 Journal Article
%1 Gold_2005_122
%A Goldhaber, Joshua I
%A Henderson, Scott A
%A Reuter, Hannes
%A Pott, Christian
%A Philipson, Kenneth D
%D 2005
%J Ann. N. Y. Acad. Sci.
%K 16093490 Action Animals, Ca, Calcium, Cardiac, Cardiomegaly, Contraction, Disease, Electrophysiology, Energy Exchanger, Extramural, Genetic Gov't, Homozygote, Injury, Isoproterenol, Knockout, Metabolism, Mice, Myocardial Myocardium, Myocytes, N.I.H., Non-U.S. P.H.S., Phenotype, Potentials, Predisposition Reperfusion Research Sarcolemma, Sodium, Sodium-Calcium Support, Transgenic, U.S. lcium, to
%P 122--126
%R 10.1196/annals.1341.011
%T Effects of Na$^+$-Ca$^2+$ exchange expression on excitation-contraction
coupling in genetically modified mice.
%U http://dx.doi.org/10.1196/annals.1341.011
%V 1047
%X We have created genetically altered mice to investigate how expression
of the Na$^+$-Ca$^2+$ exchange protein alters excitation-contraction
(E-C) coupling. Whereas low levels of exchanger overexpression have
minimal effects on E-C coupling properties, high levels of overexpression
in homozygous animals results in susceptibility to hypertrophy and
heart failure, along with a significant reduction in E-C coupling
gain. While global knockout of the exchanger in mice is embryonic-lethal,
conditional knockout mice live to adulthood. Cardiac function is
surprisingly normal in seven-week-old mice, but E-C coupling gain
is apparently increased. Thus, genetic modification of exchanger
expression has a major influence on E-C coupling.
@article{Gold_2005_122,
abstract = {We have created genetically altered mice to investigate how expression
of the {N}a$^{+}$-{C}a$^{2+}$ exchange protein alters excitation-contraction
(E-C) coupling. Whereas low levels of exchanger overexpression have
minimal effects on E-C coupling properties, high levels of overexpression
in homozygous animals results in susceptibility to hypertrophy and
heart failure, along with a significant reduction in E-C coupling
gain. While global knockout of the exchanger in mice is embryonic-lethal,
conditional knockout mice live to adulthood. Cardiac function is
surprisingly normal in seven-week-old mice, but E-C coupling gain
is apparently increased. Thus, genetic modification of exchanger
expression has a major influence on E-C coupling.},
added-at = {2009-06-03T11:20:58.000+0200},
author = {Goldhaber, Joshua I and Henderson, Scott A and Reuter, Hannes and Pott, Christian and Philipson, Kenneth D},
biburl = {https://www.bibsonomy.org/bibtex/2b7784291ca7dda278540a408b2ab45c1/hake},
description = {The whole bibliography file I use.},
doi = {10.1196/annals.1341.011},
file = {Gold_2005_122.pdf:Gold_2005_122.pdf:PDF},
interhash = {748d4e150018adfa049da2fc84c25e3e},
intrahash = {b7784291ca7dda278540a408b2ab45c1},
journal = {Ann. N. Y. Acad. Sci.},
keywords = {16093490 Action Animals, Ca, Calcium, Cardiac, Cardiomegaly, Contraction, Disease, Electrophysiology, Energy Exchanger, Extramural, Genetic Gov't, Homozygote, Injury, Isoproterenol, Knockout, Metabolism, Mice, Myocardial Myocardium, Myocytes, N.I.H., Non-U.S. P.H.S., Phenotype, Potentials, Predisposition Reperfusion Research Sarcolemma, Sodium, Sodium-Calcium Support, Transgenic, U.S. lcium, to},
month = Jun,
pages = {122--126},
pii = {1047/1/122},
pmid = {16093490},
timestamp = {2009-06-03T11:21:12.000+0200},
title = {Effects of {N}a$^{+}$-{C}a$^{2+}$ exchange expression on excitation-contraction
coupling in genetically modified mice.},
url = {http://dx.doi.org/10.1196/annals.1341.011},
volume = 1047,
year = 2005
}