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Polymorphisms in the interleukin-1 gene cluster in children and young adults with systemic meningococcemia

, , , , , , , , , and . Clinical Chemistry, 52 (3): 511--4 (March 2006)PMID: 16510430.
DOI: 10.1373/clinchem.2005.058537

Abstract

BACKGROUND: An association has been described between mortality in children with meningococcal disease and functional polymorphisms in the interleukin-1 (IL1) cluster. We undertook a multicenter study to evaluate associations of these polymorphisms in a Central European population. PATIENTS AND METHODS: The study involved 95 Middle European pediatric hospitals. We collected blood samples from, and clinical information about, 285 previously healthy children with meningococcal infection. We used a newly developed multiplexed mutagenic separated PCR assay to analyze 6 polymorphisms within the IL1 cluster: IL1A (-889)C/T, IL1A (+4845)G/T, IL1B (-…(more)

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