Solid-state NMR spectra with single-site resolution of CXCR1, a G protein-coupled receptor (GPCR), were obtained in magnetically aligned phospholipid bicelles. These results demonstrate that GPCRs in phospholipid bilayers are suitable samples for structure determination by solid-state NMR. The spectra also enable studies of drug-receptor interactions.
%0 Journal Article
%1 park_high-resolution_2006
%A Park, Sang Ho
%A Prytulla, Stefan
%A De Angelis, Anna A
%A Brown, Jonathan Miles
%A Kiefer, Hans
%A Opella, Stanley J
%D 2006
%J J. Am. Chem. Soc.
%K Binding Proteins,Interleukin-8A,Lipid Resonance Sites,G-Protein-Coupled,GTP-Binding Spectroscopy,Protein Structure,Receptors,Secondary,Tertiary bilayers,Magnetic
%N 23
%P 7402--7403
%R 10.1021/ja0606632
%T High-resolution \NMR\ spectroscopy of a \GPCR\ in aligned bicelles
%V 128
%X Solid-state NMR spectra with single-site resolution of CXCR1, a G protein-coupled receptor (GPCR), were obtained in magnetically aligned phospholipid bicelles. These results demonstrate that GPCRs in phospholipid bilayers are suitable samples for structure determination by solid-state NMR. The spectra also enable studies of drug-receptor interactions.
@article{park_high-resolution_2006,
abstract = {Solid-state NMR spectra with single-site resolution of CXCR1, a G protein-coupled receptor (GPCR), were obtained in magnetically aligned phospholipid bicelles. These results demonstrate that GPCRs in phospholipid bilayers are suitable samples for structure determination by solid-state NMR. The spectra also enable studies of drug-receptor interactions.},
added-at = {2017-03-14T02:48:56.000+0100},
author = {Park, Sang Ho and Prytulla, Stefan and {De Angelis}, Anna A and Brown, Jonathan Miles and Kiefer, Hans and Opella, Stanley J},
biburl = {https://www.bibsonomy.org/bibtex/2bd093c3c6ef0f3ca08d86829614b48d1/nmrresource},
doi = {10.1021/ja0606632},
interhash = {5b0fc40fc1d39f41133f28faabdd5865},
intrahash = {bd093c3c6ef0f3ca08d86829614b48d1},
issn = {0002-7863},
journal = {J. Am. Chem. Soc.},
keywords = {Binding Proteins,Interleukin-8A,Lipid Resonance Sites,G-Protein-Coupled,GTP-Binding Spectroscopy,Protein Structure,Receptors,Secondary,Tertiary bilayers,Magnetic},
month = jun,
number = 23,
pages = {7402--7403},
pmid = {16756269},
timestamp = {2017-03-14T02:49:21.000+0100},
title = {{High-resolution {\{}NMR{\}} spectroscopy of a {\{}GPCR{\}} in aligned bicelles}},
volume = 128,
year = 2006
}