Gut microbial communities represent one source of human genetic and metabolic diversity. To examine how gut microbiomes differ among human populations, here we characterize bacterial species in fecal samples from 531 individuals, plus the gene content of 110 of them. The cohort encompassed healthy children and adults from the Amazonas of Venezuela, rural Malawi and US metropolitan areas and included mono- and dizygotic twins. Shared features of the functional maturation of the gut microbiome were identified during the first three years of life in all three populations, including age-associated changes in the genes involved in vitamin biosynthesis and metabolism. Pronounced differences in bacterial assemblages and functional gene repertoires were noted between US residents and those in the other two countries. These distinctive features are evident in early infancy as well as adulthood. Our findings underscore the need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization.
%0 Journal Article
%1 Yatsunenko2012Human
%A Yatsunenko, Tanya
%A Rey, Federico E.
%A Manary, Mark J.
%A Trehan, Indi
%A Dominguez-Bello, Maria Gloria G.
%A Contreras, Monica
%A Magris, Magda
%A Hidalgo, Glida
%A Baldassano, Robert N.
%A Anokhin, Andrey P.
%A Heath, Andrew C.
%A Warner, Barbara
%A Reeder, Jens
%A Kuczynski, Justin
%A Caporaso, J. Gregory
%A Lozupone, Catherine A.
%A Lauber, Christian
%A Clemente, Jose Carlos C.
%A Knights, Dan
%A Knight, Rob
%A Gordon, Jeffrey I.
%D 2012
%I Nature Publishing Group
%J Nature
%K gut-microbiome
%N 7402
%P 222--227
%R 10.1038/nature11053
%T Human gut microbiome viewed across age and geography.
%U http://dx.doi.org/10.1038/nature11053
%V 486
%X Gut microbial communities represent one source of human genetic and metabolic diversity. To examine how gut microbiomes differ among human populations, here we characterize bacterial species in fecal samples from 531 individuals, plus the gene content of 110 of them. The cohort encompassed healthy children and adults from the Amazonas of Venezuela, rural Malawi and US metropolitan areas and included mono- and dizygotic twins. Shared features of the functional maturation of the gut microbiome were identified during the first three years of life in all three populations, including age-associated changes in the genes involved in vitamin biosynthesis and metabolism. Pronounced differences in bacterial assemblages and functional gene repertoires were noted between US residents and those in the other two countries. These distinctive features are evident in early infancy as well as adulthood. Our findings underscore the need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization.
@article{Yatsunenko2012Human,
abstract = {Gut microbial communities represent one source of human genetic and metabolic diversity. To examine how gut microbiomes differ among human populations, here we characterize bacterial species in fecal samples from 531 individuals, plus the gene content of 110 of them. The cohort encompassed healthy children and adults from the Amazonas of Venezuela, rural Malawi and {US} metropolitan areas and included mono- and dizygotic twins. Shared features of the functional maturation of the gut microbiome were identified during the first three years of life in all three populations, including age-associated changes in the genes involved in vitamin biosynthesis and metabolism. Pronounced differences in bacterial assemblages and functional gene repertoires were noted between {US} residents and those in the other two countries. These distinctive features are evident in early infancy as well as adulthood. Our findings underscore the need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization.},
added-at = {2018-12-02T16:09:07.000+0100},
author = {Yatsunenko, Tanya and Rey, Federico E. and Manary, Mark J. and Trehan, Indi and Dominguez-Bello, Maria Gloria G. and Contreras, Monica and Magris, Magda and Hidalgo, Glida and Baldassano, Robert N. and Anokhin, Andrey P. and Heath, Andrew C. and Warner, Barbara and Reeder, Jens and Kuczynski, Justin and Caporaso, J. Gregory and Lozupone, Catherine A. and Lauber, Christian and Clemente, Jose Carlos C. and Knights, Dan and Knight, Rob and Gordon, Jeffrey I.},
biburl = {https://www.bibsonomy.org/bibtex/2bdd88ba6cdd969fe099fac4229c7ef39/karthikraman},
citeulike-article-id = {10655920},
citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature11053},
citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature11053},
citeulike-linkout-2 = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376388/},
citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/22699611},
citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=22699611},
day = 14,
doi = {10.1038/nature11053},
interhash = {01d7aadffad45998923b8dc62f683a9f},
intrahash = {bdd88ba6cdd969fe099fac4229c7ef39},
issn = {1476-4687},
journal = {Nature},
keywords = {gut-microbiome},
month = jun,
number = 7402,
pages = {222--227},
pmcid = {PMC3376388},
pmid = {22699611},
posted-at = {2012-06-18 07:31:48},
priority = {5},
publisher = {Nature Publishing Group},
timestamp = {2018-12-02T16:09:07.000+0100},
title = {Human gut microbiome viewed across age and geography.},
url = {http://dx.doi.org/10.1038/nature11053},
volume = 486,
year = 2012
}