Muscle biopsy was examined in 20 children with cerebral palsy, using immunohistochemical methods for marker of denervation neural cell adhesion molecules (N-CAM) in addition to standard techniques. Histological and histochemical study showed mild myopathic changes, type 1 predominance, and type 1 and type 2 hypotrophy, in accord with previous observations. Immunohistochemical study showed N-CAM expression in most biopsies (15/20), usually in scattered fibers, whereas in four patients aged less than 6 years it was expressed in grouped fibers. Our study supports the hypothesis of motor unit remodeling as a consequence of spasticity, especially in early phases of the disease.
%0 Journal Article
%1 Marbini2002
%A Marbini, Adriana
%A Ferrari, A.
%A Cioni, G.
%A Bellanova, M. F.
%A Fusco, C.
%A Gemignani, F.
%D 2002
%J Brain Dev
%K Adolescent; Biopsy; Cerebral Palsy; Child; Child, Preschool; Female; Humans; Immunohistochemistry; Male; Muscle Fibers, Fast-Twitch; Slow-Twitch; Spasticity; Muscle, Skeletal; Muscular Atrophy; Neural Cell Adhesion Molecules
%N 2
%P 63--66
%T Immunohistochemical study of muscle biopsy in children with cerebral palsy.
%V 24
%X Muscle biopsy was examined in 20 children with cerebral palsy, using immunohistochemical methods for marker of denervation neural cell adhesion molecules (N-CAM) in addition to standard techniques. Histological and histochemical study showed mild myopathic changes, type 1 predominance, and type 1 and type 2 hypotrophy, in accord with previous observations. Immunohistochemical study showed N-CAM expression in most biopsies (15/20), usually in scattered fibers, whereas in four patients aged less than 6 years it was expressed in grouped fibers. Our study supports the hypothesis of motor unit remodeling as a consequence of spasticity, especially in early phases of the disease.
@article{Marbini2002,
abstract = {Muscle biopsy was examined in 20 children with cerebral palsy, using immunohistochemical methods for marker of denervation neural cell adhesion molecules (N-CAM) in addition to standard techniques. Histological and histochemical study showed mild myopathic changes, type 1 predominance, and type 1 and type 2 hypotrophy, in accord with previous observations. Immunohistochemical study showed N-CAM expression in most biopsies (15/20), usually in scattered fibers, whereas in four patients aged less than 6 years it was expressed in grouped fibers. Our study supports the hypothesis of motor unit remodeling as a consequence of spasticity, especially in early phases of the disease.},
added-at = {2014-07-19T20:45:36.000+0200},
author = {Marbini, Adriana and Ferrari, A. and Cioni, G. and Bellanova, M. F. and Fusco, C. and Gemignani, F.},
biburl = {https://www.bibsonomy.org/bibtex/2bf7dcd70209e7cb8d5da1c40d0f94f9a/ar0berts},
groups = {public},
interhash = {41140a671704a86d0d41e221bfec60ca},
intrahash = {bf7dcd70209e7cb8d5da1c40d0f94f9a},
journal = {Brain Dev},
keywords = {Adolescent; Biopsy; Cerebral Palsy; Child; Child, Preschool; Female; Humans; Immunohistochemistry; Male; Muscle Fibers, Fast-Twitch; Slow-Twitch; Spasticity; Muscle, Skeletal; Muscular Atrophy; Neural Cell Adhesion Molecules},
month = Mar,
number = 2,
pages = {63--66},
pii = {S0387760401003941},
pmid = {11891093},
timestamp = {2014-07-19T20:45:36.000+0200},
title = {Immunohistochemical study of muscle biopsy in children with cerebral palsy.},
username = {ar0berts},
volume = 24,
year = 2002
}