Proton-enhanced 13C nuclear magnetic resonance is used to obtain signals from labeled cholesterols in lecithin dispersions. The 26-(13)Ccholesterol resonance indicates that the aliphatic tail of the molecule undergoes reorientation fast enough to average completely the chemical shift anisotropy. In contrast, 4-(13)Ccholesterol signals are characteristic of limited anisotropic reorientation. The resonances from the 4 position are sensitive to the temperature-concentration phase diagram. A phase boundary is observed at about 20 mole percent cholesterol.
%0 Journal Article
%1 opella_nuclear_1976
%A Opella, S J
%A Yesinowski, J P
%A Waugh, J S
%D 1976
%J Proc. Natl. Acad. Sci. U.S.A.
%K Chemistry,Cholesterol,Magnetic Lipids,Motion,Physical,Physicochemical Phenomena,Pulmonary Resonance Spectroscopy,Membrane Surfactants,Temperature
%N 11
%P 3812--3815
%T Nuclear magnetic resonance description of molecular motion and phase separations of cholesterol in lecithin dispersions
%V 73
%X Proton-enhanced 13C nuclear magnetic resonance is used to obtain signals from labeled cholesterols in lecithin dispersions. The 26-(13)Ccholesterol resonance indicates that the aliphatic tail of the molecule undergoes reorientation fast enough to average completely the chemical shift anisotropy. In contrast, 4-(13)Ccholesterol signals are characteristic of limited anisotropic reorientation. The resonances from the 4 position are sensitive to the temperature-concentration phase diagram. A phase boundary is observed at about 20 mole percent cholesterol.
@article{opella_nuclear_1976,
abstract = {Proton-enhanced 13C nuclear magnetic resonance is used to obtain signals from labeled cholesterols in lecithin dispersions. The [26-(13)C]cholesterol resonance indicates that the aliphatic tail of the molecule undergoes reorientation fast enough to average completely the chemical shift anisotropy. In contrast, [4-(13)C]cholesterol signals are characteristic of limited anisotropic reorientation. The resonances from the 4 position are sensitive to the temperature-concentration phase diagram. A phase boundary is observed at about 20 mole percent cholesterol.},
added-at = {2017-03-14T02:48:56.000+0100},
author = {Opella, S J and Yesinowski, J P and Waugh, J S},
biburl = {https://www.bibsonomy.org/bibtex/2c5cf945816c058edc70eb0d1dbd0d58f/nmrresource},
interhash = {78fd1c6ec145d39df5816a78f517bce5},
intrahash = {c5cf945816c058edc70eb0d1dbd0d58f},
issn = {0027-8424},
journal = {Proc. Natl. Acad. Sci. U.S.A.},
keywords = {Chemistry,Cholesterol,Magnetic Lipids,Motion,Physical,Physicochemical Phenomena,Pulmonary Resonance Spectroscopy,Membrane Surfactants,Temperature},
month = nov,
number = 11,
pages = {3812--3815},
pmid = {1069266},
timestamp = {2017-03-14T02:49:21.000+0100},
title = {{Nuclear magnetic resonance description of molecular motion and phase separations of cholesterol in lecithin dispersions}},
volume = 73,
year = 1976
}