OBJECTIVE: Flicker light-induced retinal vasodilation may reflect endothelial
function in the retinal circulation. We investigated flicker light-induced
vasodilation in individuals with diabetes and diabetic retinopathy. RESEARCH
DESIGN AND METHODS: Participants consisted of 224 individuals with diabetes and
103 nondiabetic control subjects. Flicker light-induced retinal vasodilation
(percentage increase over baseline diameter) was measured using the Dynamic
Vessel Analyzer. Diabetic retinopathy was graded from retinal photographs.
RESULTS: Mean +/- SD age was 56.5 +/- 11.8 years for those with diabetes and 48.0
+/- 16.3 years for control subjects. Mean arteriolar and venular dilation after
flicker light stimulation were reduced in participants with diabetes compared
with those in control subjects (1.43 +/- 2.10 vs. 3.46 +/- 2.36\%, P < 0.001 for
arteriolar and 2.83 +/- 2.10 vs. 3.98 +/- 1.84\%, P < 0.001 for venular dilation).
After adjustment for age, sex, diabetes duration, fasting glucose, cholesterol
and triglyceride levels, current smoking status, systolic blood pressure, and use
of antihypertensive and lipid-lowering medications, participants with reduced
flicker light-induced vasodilation were more likely to have diabetes (odds ratio
19.7 95\% CI 6.5-59.1, P < 0.001 and 8.14 3.1-21.4, P < 0.001, comparing
lowest vs. highest tertile of arteriolar and venular dilation, respectively).
Diabetic participants with reduced flicker light-induced vasodilation were more
likely to have diabetic retinopathy (2.2 1.2-4.0, P = 0.01 for arteriolar
dilation and 2.5 1.3-4.5, P = 0.004 for venular dilation). CONCLUSIONS: Reduced
retinal vasodilation after flicker light stimulation is independently associated
with diabetes status and, in individuals with diabetes, with diabetic
retinopathy. Our findings may therefore support endothelial dysfunction as a
pathophysiological mechanism underlying diabetes and its microvascular
manifestations.
%0 Journal Article
%1 Nguyen.2009
%A Nguyen, Thanh T.
%A Kawasaki, R.
%A Wang, J. J.
%A Kreis, A. J.
%A Shaw, J.
%A Vilser, W.
%A Wong, T. Y.
%D 2009
%J Diabetes care
%K (Cholesterol);Adult;Aged;Arterioles/physiology/physiopathology/radiation (Hemoglobin (Triglycerides);57-88-5 0 1/blood/physiopathology;Diabetes 2/blood/physiopathology;Diabetic A, Aged;Reference Factors;Triglycerides/blood;Vasodilation/physiology/*radiation Fusion/*physiology;Hemoglobin Glycosylated);0 Glycosylated/metabolism;Humans;Light;Middle Mellitus, Mellitus/blood/*physiopathology;Diabetes Retinopathy/blood/*physiopathology;Flicker Type Values;Retina/*physiology/radiation WViCo effects effects;Cholesterol/blood;Diabetes effects;Risk effects;Venules/physiology/physiopathology/radiation
%N 11
%P 2075--2080
%R 10.2337/dc09-0075
%T Flicker light-induced retinal vasodilation in diabetes and diabetic retinopathy
%V 32
%X OBJECTIVE: Flicker light-induced retinal vasodilation may reflect endothelial
function in the retinal circulation. We investigated flicker light-induced
vasodilation in individuals with diabetes and diabetic retinopathy. RESEARCH
DESIGN AND METHODS: Participants consisted of 224 individuals with diabetes and
103 nondiabetic control subjects. Flicker light-induced retinal vasodilation
(percentage increase over baseline diameter) was measured using the Dynamic
Vessel Analyzer. Diabetic retinopathy was graded from retinal photographs.
RESULTS: Mean +/- SD age was 56.5 +/- 11.8 years for those with diabetes and 48.0
+/- 16.3 years for control subjects. Mean arteriolar and venular dilation after
flicker light stimulation were reduced in participants with diabetes compared
with those in control subjects (1.43 +/- 2.10 vs. 3.46 +/- 2.36\%, P < 0.001 for
arteriolar and 2.83 +/- 2.10 vs. 3.98 +/- 1.84\%, P < 0.001 for venular dilation).
After adjustment for age, sex, diabetes duration, fasting glucose, cholesterol
and triglyceride levels, current smoking status, systolic blood pressure, and use
of antihypertensive and lipid-lowering medications, participants with reduced
flicker light-induced vasodilation were more likely to have diabetes (odds ratio
19.7 95\% CI 6.5-59.1, P < 0.001 and 8.14 3.1-21.4, P < 0.001, comparing
lowest vs. highest tertile of arteriolar and venular dilation, respectively).
Diabetic participants with reduced flicker light-induced vasodilation were more
likely to have diabetic retinopathy (2.2 1.2-4.0, P = 0.01 for arteriolar
dilation and 2.5 1.3-4.5, P = 0.004 for venular dilation). CONCLUSIONS: Reduced
retinal vasodilation after flicker light stimulation is independently associated
with diabetes status and, in individuals with diabetes, with diabetic
retinopathy. Our findings may therefore support endothelial dysfunction as a
pathophysiological mechanism underlying diabetes and its microvascular
manifestations.
@article{Nguyen.2009,
abstract = {OBJECTIVE: Flicker light-induced retinal vasodilation may reflect endothelial
function in the retinal circulation. We investigated flicker light-induced
vasodilation in individuals with diabetes and diabetic retinopathy. RESEARCH
DESIGN AND METHODS: Participants consisted of 224 individuals with diabetes and
103 nondiabetic control subjects. Flicker light-induced retinal vasodilation
(percentage increase over baseline diameter) was measured using the Dynamic
Vessel Analyzer. Diabetic retinopathy was graded from retinal photographs.
RESULTS: Mean +/- SD age was 56.5 +/- 11.8 years for those with diabetes and 48.0
+/- 16.3 years for control subjects. Mean arteriolar and venular dilation after
flicker light stimulation were reduced in participants with diabetes compared
with those in control subjects (1.43 +/- 2.10 vs. 3.46 +/- 2.36{\%}, P < 0.001 for
arteriolar and 2.83 +/- 2.10 vs. 3.98 +/- 1.84{\%}, P < 0.001 for venular dilation).
After adjustment for age, sex, diabetes duration, fasting glucose, cholesterol
and triglyceride levels, current smoking status, systolic blood pressure, and use
of antihypertensive and lipid-lowering medications, participants with reduced
flicker light-induced vasodilation were more likely to have diabetes (odds ratio
19.7 [95{\%} CI 6.5-59.1], P < 0.001 and 8.14 [3.1-21.4], P < 0.001, comparing
lowest vs. highest tertile of arteriolar and venular dilation, respectively).
Diabetic participants with reduced flicker light-induced vasodilation were more
likely to have diabetic retinopathy (2.2 [1.2-4.0], P = 0.01 for arteriolar
dilation and 2.5 [1.3-4.5], P = 0.004 for venular dilation). CONCLUSIONS: Reduced
retinal vasodilation after flicker light stimulation is independently associated
with diabetes status and, in individuals with diabetes, with diabetic
retinopathy. Our findings may therefore support endothelial dysfunction as a
pathophysiological mechanism underlying diabetes and its microvascular
manifestations.},
added-at = {2013-10-10T21:29:09.000+0200},
author = {Nguyen, Thanh T. and Kawasaki, R. and Wang, J. J. and Kreis, A. J. and Shaw, J. and Vilser, W. and Wong, T. Y.},
biburl = {https://www.bibsonomy.org/bibtex/2c7fa28276e26d3b733a5eef0d855003c/imedos},
doi = {10.2337/dc09-0075},
interhash = {da6c33a4181317f3b0279db5f61da596},
intrahash = {c7fa28276e26d3b733a5eef0d855003c},
issn = {0149-5992},
journal = {Diabetes care},
keywords = {(Cholesterol);Adult;Aged;Arterioles/physiology/physiopathology/radiation (Hemoglobin (Triglycerides);57-88-5 0 1/blood/physiopathology;Diabetes 2/blood/physiopathology;Diabetic A, Aged;Reference Factors;Triglycerides/blood;Vasodilation/physiology/*radiation Fusion/*physiology;Hemoglobin Glycosylated);0 Glycosylated/metabolism;Humans;Light;Middle Mellitus, Mellitus/blood/*physiopathology;Diabetes Retinopathy/blood/*physiopathology;Flicker Type Values;Retina/*physiology/radiation WViCo effects effects;Cholesterol/blood;Diabetes effects;Risk effects;Venules/physiology/physiopathology/radiation},
number = 11,
pages = {2075--2080},
timestamp = {2013-10-11T01:11:02.000+0200},
title = {Flicker light-induced retinal vasodilation in diabetes and diabetic retinopathy},
volume = 32,
year = 2009
}