%0 Journal Article %1 Jason:2009:J-Behav-Neurosci-Res:21253446 %A Jason, L A %A Porter, N %A Herrington, J %A Sorenson, M %A Kubow, S %D 2009 %J J Behav Neurosci Res %K ACTH ATP CRH CoQ10 GABA HPA_axis Klonopin ME/CFS NMDA NMDA-receptors acetylcholine amygdala antioxidants brain_injury chronic_fatigue_syndrome cortisol dopamine epilepsy free_radicals gene_expression glutamate glutathione host_response hypersensitivity immune_system infections inflammation ion_channels kindling limbic_system mitochondria myalgic_encephalomyelitis neuroendocrinology neurotonin nitric_oxide oxidative_stress peroxynitrite redox seizures selenium serotonin stress_response superoxide_dismutase supplements viruses %N 2 %P 1-17 %T Kindling and Oxidative Stress as Contributors to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022475/?fbclid=IwAR0_JyTX4UpJrT9P300rW1S67gSuOIhJRzxmmgs5RDwCIirTyq7ymk-EsgA %V 7 %X Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS) is one of the more complex illnesses involving multiple systems within the body. Onset of ME/CFS frequently occurs quickly, and many patients report a prior exposure to a viral infection. This debilitating illness can affect the immune, neuroendocrine, autonomic, and neurologic systems. Abnormal biological findings among some patients have included aberrant ion transport and ion channel activity, cortisol deficiency, sympathetic nervous system hyperactivity, EEG spike waves, left ventricular dysfunction in the heart, low natural killer cell cytotoxicity, and a shift from Th1 to Th2 cytokines. We propose that the kindling and oxidative stress theories provide a heuristic template for better understanding the at times conflicting findings regarding the etiology and pathophysiology of this illness.

@article{Jason:2009:J-Behav-Neurosci-Res:21253446, abstract = {Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS) is one of the more complex illnesses involving multiple systems within the body. Onset of ME/CFS frequently occurs quickly, and many patients report a prior exposure to a viral infection. This debilitating illness can affect the immune, neuroendocrine, autonomic, and neurologic systems. Abnormal biological findings among some patients have included aberrant ion transport and ion channel activity, cortisol deficiency, sympathetic nervous system hyperactivity, EEG spike waves, left ventricular dysfunction in the heart, low natural killer cell cytotoxicity, and a shift from Th1 to Th2 cytokines. We propose that the kindling and oxidative stress theories provide a heuristic template for better understanding the at times conflicting findings regarding the etiology and pathophysiology of this illness.}, added-at = {2019-06-05T22:52:55.000+0200}, author = {Jason, L A and Porter, N and Herrington, J and Sorenson, M and Kubow, S}, biburl = {https://www.bibsonomy.org/bibtex/2ca2a2abac8d8e663c88443588a59950e/eirc}, description = {An exciting and important paper on the limbic kindling model for Myalgic Encephalomyelitis (Chronic Fatigue Syndrome). The root problem of MCS/ES is increasingly believed to share the same mechanisms as ME/CFS: neural sensitization via limbic kindling.}, interhash = {651c913d9f662d3ecd5edd82b015dad4}, intrahash = {ca2a2abac8d8e663c88443588a59950e}, journal = {J Behav Neurosci Res}, keywords = {ACTH ATP CRH CoQ10 GABA HPA_axis Klonopin ME/CFS NMDA NMDA-receptors acetylcholine amygdala antioxidants brain_injury chronic_fatigue_syndrome cortisol dopamine epilepsy free_radicals gene_expression glutamate glutathione host_response hypersensitivity immune_system infections inflammation ion_channels kindling limbic_system mitochondria myalgic_encephalomyelitis neuroendocrinology neurotonin nitric_oxide oxidative_stress peroxynitrite redox seizures selenium serotonin stress_response superoxide_dismutase supplements viruses}, month = jan, number = 2, pages = {1-17}, pmid = {21253446}, timestamp = {2019-06-19T23:32:54.000+0200}, title = {Kindling and Oxidative Stress as Contributors to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022475/?fbclid=IwAR0_JyTX4UpJrT9P300rW1S67gSuOIhJRzxmmgs5RDwCIirTyq7ymk-EsgA}, volume = 7, year = 2009 }