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A 3D electromechanical FEM-based model for cardiac tissue

, , , and . Proceedings of the VII European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS Congress 2016), page 63--73. Athens, Institute of Structural Analysis and Antiseismic Research School of Civil Engineering National Technical University of Athens (NTUA) Greece, (2016)
DOI: 10.7712/100016.1791.11367

Abstract

The CellDrum provides an experimental setup to investigate the electromechanics of a cardiac tissue construct and particularly the effect of drugs. Experimental data were used to develop a respective computational electromechanical model. Until now, the experiments have been performed with a thin tissue construct. Mechanically, it was modeled as a materially and geometrically nonlinear shell. Future experiments with thicker tissue are planned. Thus, the mechanical model needs to be modified. This study aims to predict the outcome of such experiments using a nonlinear 3D continuum formulation. Here, the action of one drug, verapamil, was taken into account.

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