Three-dimensional models of individual cardiac histoanatomy: tools
and challenges.
Ann. N. Y. Acad. Sci., (October 2006)DOI: 10.1196/annals.1380.023
Abstract
There is a need for, and utility in, the acquisition of data sets
of cardiac histoanatomy, with the vision of reconstructing individual
hearts on the basis of noninvasive imaging, such as MRI, enriched
by reference to detailed atlases of serial histology obtained from
representative samples. These data sets would be useful not only
as a repository of knowledge regarding the specifics of cardiac histoanatomy,
but could form the basis for generation of individualized high-resolution
cardiac structure-function models. The current article presents a
step in this general direction: it illustrates how whole-heart noninvasive
imaging can be combined with whole-heart histology in an approach
to achieve automated construction of histoanatomically detailed models
of cardiac 3D structure and function at hitherto unprecedented resolution
and accuracy (based on 26.4 x 26.4 x 24.4 microm MRI voxel size,
and enriched by histological detail). It provides an overview of
the tools used in this quest and outlines challenges posed by the
approach in the light of applications that may benefit from the availability
of such data and tools.
Description
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