%0 Journal Article %1 ren %A Rennard, SI %C 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 %D 1996 %I MOSBY-YEAR BOOK INC %J JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY %K asthma repair %N 6, Part 2, S %P S278-S286 %R 10.1016/S0091-6749(96)70076-3 %T Repair mechanisms in asthma %V 98 %X Asthma is classically defined in terms of reversible airflow obstruction. It is now recognized that histologic abnormalities, including inflammation, are a regular feature of asthma. In addition, alterations of the structural elements of the airway wall occur regularly in asthma. These alterations include a thickened basal lamina comprised of interstitial collagens as well as alterations in the mesenchymal cell population with an accumulation of myofibroblasts. It seems likely that these connective tissue alterations in the airway wall contribute to the physiologic abnormalities of asthma. While controversial, the long-term physiologic sequela of asthma may depend in large part on these changes. The biochemical and cellular basis that leads to these changes is, as yet, unknown, but recent studies suggest that a variety of cells in the airway, including inflammatory cells and the cells of the airway epithelium, may participate in regulating this response.

@article{ren, abstract = {{Asthma is classically defined in terms of reversible airflow obstruction. It is now recognized that histologic abnormalities, including inflammation, are a regular feature of asthma. In addition, alterations of the structural elements of the airway wall occur regularly in asthma. These alterations include a thickened basal lamina comprised of interstitial collagens as well as alterations in the mesenchymal cell population with an accumulation of myofibroblasts. It seems likely that these connective tissue alterations in the airway wall contribute to the physiologic abnormalities of asthma. While controversial, the long-term physiologic sequela of asthma may depend in large part on these changes. The biochemical and cellular basis that leads to these changes is, as yet, unknown, but recent studies suggest that a variety of cells in the airway, including inflammatory cells and the cells of the airway epithelium, may participate in regulating this response.}}, added-at = {2013-01-07T12:03:33.000+0100}, address = {{11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318}}, affiliation = {{Rennard, SI (Reprint Author), UNIV NEBRASKA,MED CTR,PULM \& CRIT CARE MED SECT,600 S 42ND ST,OMAHA,NE 68198, USA..}}, author = {Rennard, SI}, biburl = {https://www.bibsonomy.org/bibtex/2ca50f171f61e3980856e8007a94e0048/jehiorns}, doc-delivery-number = {{WC447}}, doi = {{10.1016/S0091-6749(96)70076-3}}, interhash = {2d482b13fc84ab582546170b236c1737}, intrahash = {ca50f171f61e3980856e8007a94e0048}, issn = {{0091-6749}}, journal = {{JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY}}, journal-iso = {{J. Allergy Clin. Immunol.}}, keywords = {asthma repair}, keywords-plus = {{BRONCHIAL EPITHELIAL-CELLS; GROWTH-FACTOR-BETA; HUMAN NEUTROPHIL ELASTASE; RAT TRACHEAL EPITHELIUM; AIRWAY INFLAMMATION; LUNG-FUNCTION; FIBRONECTIN PRODUCTION; RESPIRATORY SYMPTOMS; PULMONARY-FUNCTION; BASEMENT-MEMBRANE}}, language = {{English}}, month = {{DEC}}, number = {{6, Part 2, S}}, number-of-cited-references = {{84}}, pages = {{S278-S286}}, publisher = {{MOSBY-YEAR BOOK INC}}, research-areas = {{Allergy; Immunology}}, times-cited = {{34}}, timestamp = {2013-01-07T12:03:33.000+0100}, title = {{Repair mechanisms in asthma}}, type = {{Article}}, unique-id = {{ISI:A1996WC44700014}}, volume = {{98}}, web-of-science-categories = {{Allergy; Immunology}}, year = {{1996}} }