Flicker observation light induces diameter response in retinal arterioles: a clinical methodological study
E. Nagel, and W. Vilser. The British journal of ophthalmology, 88 (1):
54--56(2004)
Abstract
AIM: To investigate diameter changes in retinal arterioles in response to flicker
variations of the examination light. METHODS: One randomised eye of five healthy
subjects (mean age 33.8 (SD 1.6) years) was examined. The arterial diameter
response to flicker light (12.5 Hz, 530-600 nm, duration 20 seconds) was
automatically and continuously measured online three times by retinal vessel
analyser (RVA) and once offline from flash images using the VesselMap program.
RESULTS: An arterial diameter response to flicker light was found both by RVA and
by analysis of flash images (p<0.001). The maximum induced dilation reached at
the end of the flicker period was +7.4\% (SD 2.4\%) in the RVA measurements and
+3.5\% (0.8\%) in the photographs (p = 0.01). In both techniques the vascular
diameter overshot the baseline approximately 10 seconds. In the RVA measurements
a minimum of -4.6\% (1.9\%) (p = 0.01) was measured 22 (4.7) seconds after the end
of flicker exposure. CONCLUSION: Flicker evoked response for retinal arterioles
was found both by RVA and by analysis of flash images. The authors believe that
the method is suitable for the quantitative investigation of retinal
vasosclerosis, especially in association with arteriosclerotic and hypertensive
systemic disease.
%0 Journal Article
%1 Nagel.2004b
%A Nagel, E.
%A Vilser, W.
%D 2004
%J The British journal of ophthalmology
%K Adult;Analysis Artery/*physiology;Vasodilation/*physiology Computer-Assisted;Photic Ophthalmological;Humans;Image Processing, Stimulation/*methods;Retinal Techniques, Variance;Arterioles/physiology;Diagnostic WViCo of
%N 1
%P 54--56
%T Flicker observation light induces diameter response in retinal arterioles: a clinical methodological study
%V 88
%X AIM: To investigate diameter changes in retinal arterioles in response to flicker
variations of the examination light. METHODS: One randomised eye of five healthy
subjects (mean age 33.8 (SD 1.6) years) was examined. The arterial diameter
response to flicker light (12.5 Hz, 530-600 nm, duration 20 seconds) was
automatically and continuously measured online three times by retinal vessel
analyser (RVA) and once offline from flash images using the VesselMap program.
RESULTS: An arterial diameter response to flicker light was found both by RVA and
by analysis of flash images (p<0.001). The maximum induced dilation reached at
the end of the flicker period was +7.4\% (SD 2.4\%) in the RVA measurements and
+3.5\% (0.8\%) in the photographs (p = 0.01). In both techniques the vascular
diameter overshot the baseline approximately 10 seconds. In the RVA measurements
a minimum of -4.6\% (1.9\%) (p = 0.01) was measured 22 (4.7) seconds after the end
of flicker exposure. CONCLUSION: Flicker evoked response for retinal arterioles
was found both by RVA and by analysis of flash images. The authors believe that
the method is suitable for the quantitative investigation of retinal
vasosclerosis, especially in association with arteriosclerotic and hypertensive
systemic disease.
@article{Nagel.2004b,
abstract = {AIM: To investigate diameter changes in retinal arterioles in response to flicker
variations of the examination light. METHODS: One randomised eye of five healthy
subjects (mean age 33.8 (SD 1.6) years) was examined. The arterial diameter
response to flicker light (12.5 Hz, 530-600 nm, duration 20 seconds) was
automatically and continuously measured online three times by retinal vessel
analyser (RVA) and once offline from flash images using the VesselMap program.
RESULTS: An arterial diameter response to flicker light was found both by RVA and
by analysis of flash images (p<0.001). The maximum induced dilation reached at
the end of the flicker period was +7.4{\%} (SD 2.4{\%}) in the RVA measurements and
+3.5{\%} (0.8{\%}) in the photographs (p = 0.01). In both techniques the vascular
diameter overshot the baseline approximately 10 seconds. In the RVA measurements
a minimum of -4.6{\%} (1.9{\%}) (p = 0.01) was measured 22 (4.7) seconds after the end
of flicker exposure. CONCLUSION: Flicker evoked response for retinal arterioles
was found both by RVA and by analysis of flash images. The authors believe that
the method is suitable for the quantitative investigation of retinal
vasosclerosis, especially in association with arteriosclerotic and hypertensive
systemic disease.},
added-at = {2013-10-10T21:29:09.000+0200},
author = {Nagel, E. and Vilser, W.},
biburl = {https://www.bibsonomy.org/bibtex/2d6a86ff47ee584f0536ed5f6bce088e7/imedos},
interhash = {0d647b5ec275e28bdf8668f5b45f13b1},
intrahash = {d6a86ff47ee584f0536ed5f6bce088e7},
issn = {0007-1161},
journal = {The British journal of ophthalmology},
keywords = {Adult;Analysis Artery/*physiology;Vasodilation/*physiology Computer-Assisted;Photic Ophthalmological;Humans;Image Processing, Stimulation/*methods;Retinal Techniques, Variance;Arterioles/physiology;Diagnostic WViCo of},
number = 1,
pages = {54--56},
timestamp = {2013-10-11T01:11:02.000+0200},
title = {Flicker observation light induces diameter response in retinal arterioles: a clinical methodological study},
volume = 88,
year = 2004
}