%0 Journal Article %1 tennessen2011parallel %A Tennessen, Jacob A. %A Akey, Joshua M. %D 2011 %I Public Library of Science %J PLoS Genet %K humans parallel_adaptation population_genomics %N 6 %P e1002127 %R 10.1371/journal.pgen.1002127 %T Parallel Adaptive Divergence among Geographically Diverse Human Populations %U http://dx.doi.org/10.1371%2Fjournal.pgen.1002127 %V 7 %X Author Summary Identifying regions of the human genome that differ among populations because of natural selection is both essential for understanding evolutionary history and a powerful method for finding functionally important variants that contribute to phenotypic diversity and disease. Adaptive events on timescales corresponding to the human diaspora may often manifest as relatively small changes in allele frequencies at numerous loci that are difficult to distinguish from stochastic changes due to genetic drift, rather than the more dramatic selective sweeps described by classic models of natural selection. In order to test whether a substantial proportion of interpopulation genetic differences are indeed adaptive, we identify loci that have undergone moderate allele frequency changes in multiple independent human lineages, and we test whether these parallel divergence events are more frequent than expected by chance. We report a significant excess of polymorphisms showing parallel divergence, especially within genes, a pattern that is best explained by geographically varying natural selection. Our results indicate that local adaptation in humans has occurred by subtle, repeated changes at particular genes that are likely to be associated with important morphological and physiological differences among human populations.

@article{tennessen2011parallel, abstract = { Author Summary Identifying regions of the human genome that differ among populations because of natural selection is both essential for understanding evolutionary history and a powerful method for finding functionally important variants that contribute to phenotypic diversity and disease. Adaptive events on timescales corresponding to the human diaspora may often manifest as relatively small changes in allele frequencies at numerous loci that are difficult to distinguish from stochastic changes due to genetic drift, rather than the more dramatic selective sweeps described by classic models of natural selection. In order to test whether a substantial proportion of interpopulation genetic differences are indeed adaptive, we identify loci that have undergone moderate allele frequency changes in multiple independent human lineages, and we test whether these parallel divergence events are more frequent than expected by chance. We report a significant excess of polymorphisms showing parallel divergence, especially within genes, a pattern that is best explained by geographically varying natural selection. Our results indicate that local adaptation in humans has occurred by subtle, repeated changes at particular genes that are likely to be associated with important morphological and physiological differences among human populations. }, added-at = {2011-06-17T04:28:29.000+0200}, author = {Tennessen, Jacob A. and Akey, Joshua M.}, biburl = {https://www.bibsonomy.org/bibtex/2e55d8ccaf616f01bcb8c26b01c0ea96b/peter.ralph}, doi = {10.1371/journal.pgen.1002127}, interhash = {b20506ed6cdb2b9d7961b50d3a95a920}, intrahash = {e55d8ccaf616f01bcb8c26b01c0ea96b}, journal = {PLoS Genet}, keywords = {humans parallel_adaptation population_genomics}, month = {06}, number = 6, pages = {e1002127}, publisher = {Public Library of Science}, timestamp = {2011-06-17T04:28:30.000+0200}, title = {Parallel Adaptive Divergence among Geographically Diverse Human Populations}, url = {http://dx.doi.org/10.1371%2Fjournal.pgen.1002127}, volume = 7, year = 2011 }