In their plans to modify organisms, synthetic biologists have contrasted engineering and tinkering. By drawing this contrast between their endeavors and what has happened during the evolution of organisms by natural selection, they underline the novelty of their projects and justify their ambitions. Synthetic biologists are at odds with a long tradition that has considered organisms as "perfect machines." This tradition had already been questioned by Stephen Jay Gould in the 1970s and received a major blow with the comparison made by Francois Jacob between organisms and the results of "bricolage" (tinkering). These contrasts between engineering and tinkering, synthetic biology and evolution, have no raison d'être. Machines built by humans are increasingly inspired by observations made on organisms. This is not a simple reversal of the previous trend-the mechanical conception of organisms-in which the characteristics of the latter were explained by comparison with human-built machines. Relations between organisms and machines have always been complex and ambiguous.
%0 Journal Article
%1 Morange2012Synthetic
%A Morange, Michel
%D 2012
%J Perspectives in biology and medicine
%K perspective synthetic-biology
%N 4
%P 543--553
%R 10.1353/pbm.2012.0048
%T Synthetic biology: a challenge to mechanical explanations in biology?
%U http://dx.doi.org/10.1353/pbm.2012.0048
%V 55
%X In their plans to modify organisms, synthetic biologists have contrasted engineering and tinkering. By drawing this contrast between their endeavors and what has happened during the evolution of organisms by natural selection, they underline the novelty of their projects and justify their ambitions. Synthetic biologists are at odds with a long tradition that has considered organisms as "perfect machines." This tradition had already been questioned by Stephen Jay Gould in the 1970s and received a major blow with the comparison made by Francois Jacob between organisms and the results of "bricolage" (tinkering). These contrasts between engineering and tinkering, synthetic biology and evolution, have no raison d'être. Machines built by humans are increasingly inspired by observations made on organisms. This is not a simple reversal of the previous trend-the mechanical conception of organisms-in which the characteristics of the latter were explained by comparison with human-built machines. Relations between organisms and machines have always been complex and ambiguous.
@article{Morange2012Synthetic,
abstract = {
In their plans to modify organisms, synthetic biologists have contrasted engineering and tinkering. By drawing this contrast between their endeavors and what has happened during the evolution of organisms by natural selection, they underline the novelty of their projects and justify their ambitions. Synthetic biologists are at odds with a long tradition that has considered organisms as "perfect machines." This tradition had already been questioned by Stephen Jay Gould in the 1970s and received a major blow with the comparison made by Fran\c{c}ois Jacob between organisms and the results of "bricolage" (tinkering). These contrasts between engineering and tinkering, synthetic biology and evolution, have no raison d'\^{e}tre. Machines built by humans are increasingly inspired by observations made on organisms. This is not a simple reversal of the previous trend-the mechanical conception of organisms-in which the characteristics of the latter were explained by comparison with human-built machines. Relations between organisms and machines have always been complex and ambiguous.
},
added-at = {2018-12-02T16:09:07.000+0100},
author = {Morange, Michel},
biburl = {https://www.bibsonomy.org/bibtex/2e93ed409dee9bd8df25aa3a9fea3a2f4/karthikraman},
citeulike-article-id = {12749339},
citeulike-linkout-0 = {http://dx.doi.org/10.1353/pbm.2012.0048},
citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/23502563},
citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=23502563},
doi = {10.1353/pbm.2012.0048},
interhash = {263c666ce068a7d5897cc4be67ee8221},
intrahash = {e93ed409dee9bd8df25aa3a9fea3a2f4},
issn = {1529-8795},
journal = {Perspectives in biology and medicine},
keywords = {perspective synthetic-biology},
number = 4,
pages = {543--553},
pmid = {23502563},
posted-at = {2013-11-04 05:45:55},
priority = {2},
timestamp = {2018-12-02T16:09:07.000+0100},
title = {Synthetic biology: a challenge to mechanical explanations in biology?},
url = {http://dx.doi.org/10.1353/pbm.2012.0048},
volume = 55,
year = 2012
}