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GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base

, , , , , , , , , , , , , , , , , , and . Bioinformatics, 26 (14): 1804-5 (July 2010)Khelashvili, George Dorff, Kevin Shan, Jufang Camacho-Artacho, Marta Skrabanek, Lucy Vroling, Bas Bouvier, Michel Devi, Lakshmi A George, Susan R Javitch, Jonathan A Lohse, Martin J Milligan, Graeme Neubig, Richard R Palczewski, Krzysztof Parmentier, Marc Pin, Jean-Philippe Vriend, Gerrit Campagne, Fabien Filizola, Marta DA017976/DA/NIDA NIH HHS/United States Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England Bioinformatics (Oxford, England) Bioinformatics. 2010 Jul 15;26(14):1804-5. Epub 2010 May 25..

Abstract

SUMMARY: Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically. Based on an ontology derived from a community dialog involving colleagues using experimental and computational methodologies, we developed the GPCR-Oligomerization Knowledge Base (GPCR-OKB). GPCR-OKB is a system that supports browsing and searching for GPCR oligomer data. Such data were manually derived from the literature. While focused on GPCR oligomers, GPCR-OKB is seamlessly connected to GPCRDB, facilitating the correlation of information about GPCR protomers and oligomers. Availability and Implementation: The GPCR-OKB web application is freely available at http://www.gpcr-okb.org

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