Atraumatic fractures are often seen in children and adolescents with cerebral palsy (CP) and epilepsy in full-time care. Increased bone fragility was postulated to be due to osteopenia resulting from a combination of factors including immobilization and antiepileptic treatment. The aim of this study was to determine the effect of vitamin D and calcium substitution on bone mineral density (BMD) in a group of children with CP in full-time care. Twenty children with the most severe form of CP (spastic quadriplegia) who had been treated with antiepileptic drugs for a relatively long period of time were included in the study. Physical examination and laboratory analyses excluded other possible causes of osteopenia. BMD was measured by dual X-ray absorptiometry. Thirteen patients were treated for 9 months with 1,25-dihydroxy-cholecalciferol vitamin D (0.25 mcg daily) and with calcium (500 mg daily). Seven control children were used for observation only. BMD greatly increased in the treated group, while children with CP in full-time care who did not receive vitamin D and calcium substitution continued to lose their bone mass. It can be concluded that the addition of vitamin D and calcium increases BMD in children with the most severe form of CP, who are receiving antiepileptic drugs.
%0 Journal Article
%1 Jekovec-Vrhovsek2000
%A Jekovec-Vrhovsek, M.
%A Kocijancic, A.
%A Prezelj, J.
%D 2000
%J Dev Med Child Neurol
%K Adolescent; Adolescent, Institutionalized; Alkaline Phosphatase; Anticonvulsants; Bone Density; Diseases, Metabolic; Calcitriol; Calcium; Cerebral Palsy; Child; Child, Densitometry, X-Ray; Epilepsy; Female; Humans; Male; Phosphates; Treatment Outcome
%N 6
%P 403--405
%T Effect of vitamin D and calcium on bone mineral density in children with CP and epilepsy in full-time care.
%V 42
%X Atraumatic fractures are often seen in children and adolescents with cerebral palsy (CP) and epilepsy in full-time care. Increased bone fragility was postulated to be due to osteopenia resulting from a combination of factors including immobilization and antiepileptic treatment. The aim of this study was to determine the effect of vitamin D and calcium substitution on bone mineral density (BMD) in a group of children with CP in full-time care. Twenty children with the most severe form of CP (spastic quadriplegia) who had been treated with antiepileptic drugs for a relatively long period of time were included in the study. Physical examination and laboratory analyses excluded other possible causes of osteopenia. BMD was measured by dual X-ray absorptiometry. Thirteen patients were treated for 9 months with 1,25-dihydroxy-cholecalciferol vitamin D (0.25 mcg daily) and with calcium (500 mg daily). Seven control children were used for observation only. BMD greatly increased in the treated group, while children with CP in full-time care who did not receive vitamin D and calcium substitution continued to lose their bone mass. It can be concluded that the addition of vitamin D and calcium increases BMD in children with the most severe form of CP, who are receiving antiepileptic drugs.
@article{Jekovec-Vrhovsek2000,
abstract = {Atraumatic fractures are often seen in children and adolescents with cerebral palsy (CP) and epilepsy in full-time care. Increased bone fragility was postulated to be due to osteopenia resulting from a combination of factors including immobilization and antiepileptic treatment. The aim of this study was to determine the effect of vitamin D and calcium substitution on bone mineral density (BMD) in a group of children with CP in full-time care. Twenty children with the most severe form of CP (spastic quadriplegia) who had been treated with antiepileptic drugs for a relatively long period of time were included in the study. Physical examination and laboratory analyses excluded other possible causes of osteopenia. BMD was measured by dual X-ray absorptiometry. Thirteen patients were treated for 9 months with 1,25-dihydroxy-cholecalciferol vitamin D (0.25 mcg daily) and with calcium (500 mg daily). Seven control children were used for observation only. BMD greatly increased in the treated group, while children with CP in full-time care who did not receive vitamin D and calcium substitution continued to lose their bone mass. It can be concluded that the addition of vitamin D and calcium increases BMD in children with the most severe form of CP, who are receiving antiepileptic drugs.},
added-at = {2014-07-19T20:30:38.000+0200},
author = {Jekovec-Vrhovsek, M. and Kocijancic, A. and Prezelj, J.},
biburl = {https://www.bibsonomy.org/bibtex/2eaa0a3218c199e2c6970cac8f2f827b5/ar0berts},
groups = {public},
interhash = {fcb991a37af1431e7caebd402b545660},
intrahash = {eaa0a3218c199e2c6970cac8f2f827b5},
journal = {Dev Med Child Neurol},
keywords = {Adolescent; Adolescent, Institutionalized; Alkaline Phosphatase; Anticonvulsants; Bone Density; Diseases, Metabolic; Calcitriol; Calcium; Cerebral Palsy; Child; Child, Densitometry, X-Ray; Epilepsy; Female; Humans; Male; Phosphates; Treatment Outcome},
month = Jun,
number = 6,
pages = {403--405},
pmid = {10875526},
timestamp = {2014-07-19T20:30:38.000+0200},
title = {Effect of vitamin D and calcium on bone mineral density in children with CP and epilepsy in full-time care.},
username = {ar0berts},
volume = 42,
year = 2000
}