%0 Journal Article %1 Dumont.1998 %A Dumont, D. J. %A Jussila, L. %A Taipale, J. %A Lymboussaki, A. %A Mustonen, T. %A Pajusola, K. %A Breitman, M. %A Alitalo, K. %D 1998 %J Science %K Adult Animals Antigens Blood C CD31 Cardiovascular Cell Chemistry Development Embryo Embryonic Endothelial Endothelium Factor Factors Fetal Gene Growth Hematopoiesis Heterozygote Homozygote Hybridization Immunohistochemistry In Kinase Kinases Ligands Lymphatic Mammalian Mice Neovascularization Physiologic Protein-Tyrosine Receptor Receptor-3 Receptors Research Signal Situ Surface System Targeting Transduction Vascular Vessels analysis and blood embryology genetics physiology supply %N 5390 %P 946-949 %T Cardiovascular failure in mouse embryos deficient in VEGF receptor-3 %U PM:9794766 %V 282 %X Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGF-C stimulates the growth of lymphatic vessels through its specific lymphatic endothelial receptor VEGFR-3. Here it is shown that targeted inactivation of the gene encoding VEGFR-3 resulted in defective blood vessel development in early mouse embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR-3 has an essential role in the development of the embryonic cardiovascular system before the emergence of the lymphatic vessels

@article{Dumont.1998, abstract = {Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGF-C stimulates the growth of lymphatic vessels through its specific lymphatic endothelial receptor VEGFR-3. Here it is shown that targeted inactivation of the gene encoding VEGFR-3 resulted in defective blood vessel development in early mouse embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR-3 has an essential role in the development of the embryonic cardiovascular system before the emergence of the lymphatic vessels}, added-at = {2010-02-05T11:28:39.000+0100}, author = {Dumont, D. J. and Jussila, L. and Taipale, J. and Lymboussaki, A. and Mustonen, T. and Pajusola, K. and Breitman, M. and Alitalo, K.}, biburl = {https://www.bibsonomy.org/bibtex/2f972ca58089994549fd1cd42b6836c1d/kanefendt}, interhash = {cbb1fe96afe284d5e343aea5ac5bd097}, intrahash = {f972ca58089994549fd1cd42b6836c1d}, journal = {Science}, keywords = {Adult Animals Antigens Blood C CD31 Cardiovascular Cell Chemistry Development Embryo Embryonic Endothelial Endothelium Factor Factors Fetal Gene Growth Hematopoiesis Heterozygote Homozygote Hybridization Immunohistochemistry In Kinase Kinases Ligands Lymphatic Mammalian Mice Neovascularization Physiologic Protein-Tyrosine Receptor Receptor-3 Receptors Research Signal Situ Surface System Targeting Transduction Vascular Vessels analysis and blood embryology genetics physiology supply}, number = 5390, pages = {946-949}, timestamp = {2010-02-05T11:28:47.000+0100}, title = {Cardiovascular failure in mouse embryos deficient in VEGF receptor-3}, url = {PM:9794766}, volume = 282, year = 1998 }