Assessment of Allium Sativum, Zingiber Officinal Extracts on Plasmodium Berghei Infected Male Wistar Rats
INTERNATIONAL JOURNAL OF TREND IN SCIENTIFIC RESEARCH AND DEVELOPMENT, 7 (2):
412-416 (April 2023)Abstract
The aim of the study was to investigate the separate and combined effects of Allium sativum garlic and Zingiber officinale ginger on the parasite levels, liver enzymes, histology and haematological parameters. Fourty two 42 male wistar rats were assigned into seven 7 groups as mentioned below Group 1 served as negative control group and received distilled water, Group 2 served as positive control group and received 0.2ml PB I.P single dose , Group 3 received 0.2ml PB I.P single dose 500 mg kg of allium sativum Group 4 received 0.2ml PB I.P single dose 500 mg kg of zingiber officinale Group 5 received 0.2ml PB I.P single dose 250 mg kg of allium sativum 250 mg kg of zingiber officinale Group 6 received 0.2ml PB I.P single dose artemether Lumefantrine 80 480mg 4mg kg and 8mg kg Group 7 received 0.2ml PB I.P single dose Dihydroartemisini and piperaquine 30mg 225mg 2mg kg and 18mg kg . All administrations were given orally twice daily for a period of 4 days, after 3 days infection period. At the end of the treatment, three 3 male wistar rats per group were sacrificed for the first test. After, 7 days post treatment the second test was done, three 3 male wistar rats per group samples were collected for determination of hematological analysis, parasitemia levels, liver enzymes, and liver histology. Results represented as mean ± SEM were compared using One Way and Repeated measure ANOVA. It was observed that higher percentage of malaria parasitaemia seen in parasitized and untreated wistar rats were reduced in parasitized and treated groups. Allium sativum and Zingiber officinale extracts possesses no lethality in rats at 6000mg kg body weight. Overall, the results suggest that administration of the different extracts were effective in parasite clearance and none toxic. Precious Nwaka Okpa | Vincent Ugochukwu Igbokwe | Uche Dimkpa | Ikechukwu Samuel Nwaisaac | Prisca Ojochogu Ajeka | Anthonia E. Nnyaha Ässessment of Allium Sativum, Zingiber Officinal Extracts on Plasmodium Berghei Infected Male Wistar Rats" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-2 , April 2023, URL: https://www.ijtsrd.com.com/papers/ijtsrd54021.pdf Paper URL: https://www.ijtsrd.com.com/medicine/physiology/54021/assessment-of-allium-sativum-zingiber-officinal-extracts-on-plasmodium-berghei-infected-male-wistar-rats/precious-nwaka-okpa