Abstract Cells of all living organisms contain complex signal transduction networks to ensure that a wide range of physiological properties are properly adapted to the environmental conditions. The fundamental concepts and individual building blocks of these signalling networks are generally well-conserved from yeast to man; yet, the central role that growth factors and hormones play in the regulation of signalling cascades in higher eukaryotes is executed by nutrients in yeast. Several nutrient-controlled pathways, which regulate cell growth and proliferation, metabolism and stress resistance, have been defined in yeast. These pathways are integrated into a signalling network, which ensures that yeast cells enter a quiescent, resting phase (G0) to survive periods of nutrient scarceness and that they rapidly resume growth and cell proliferation when nutrient conditions become favourable again. A series of well-conserved nutrient-sensory protein kinases perform key roles in this signalling network: i.e. Snf1, PKA, Tor1 and Tor2, Sch9 and Pho85–Pho80. In this review, we provide a comprehensive overview on the current understanding of the signalling processes mediated via these kinases with a particular focus on how these individual pathways converge to signalling networks that ultimately ensure the dynamic translation of extracellular nutrient signals into appropriate physiological responses.
%0 Journal Article
%1 Smets2010Life
%A Smets, Bart
%A Ghillebert, Ruben
%A De Snijder, Pepijn
%A Binda, Matteo
%A Swinnen, Erwin
%A De Virgilio, Claudio
%A Winderickx, Joris
%D 2010
%J Current Genetics
%K signalling yeast
%N 1
%P 1--32
%R 10.1007/s00294-009-0287-1
%T Life in the midst of scarcity: adaptations to nutrient availability in Saccharomyces cerevisiae
%U http://dx.doi.org/10.1007/s00294-009-0287-1
%V 56
%X Abstract Cells of all living organisms contain complex signal transduction networks to ensure that a wide range of physiological properties are properly adapted to the environmental conditions. The fundamental concepts and individual building blocks of these signalling networks are generally well-conserved from yeast to man; yet, the central role that growth factors and hormones play in the regulation of signalling cascades in higher eukaryotes is executed by nutrients in yeast. Several nutrient-controlled pathways, which regulate cell growth and proliferation, metabolism and stress resistance, have been defined in yeast. These pathways are integrated into a signalling network, which ensures that yeast cells enter a quiescent, resting phase (G0) to survive periods of nutrient scarceness and that they rapidly resume growth and cell proliferation when nutrient conditions become favourable again. A series of well-conserved nutrient-sensory protein kinases perform key roles in this signalling network: i.e. Snf1, PKA, Tor1 and Tor2, Sch9 and Pho85–Pho80. In this review, we provide a comprehensive overview on the current understanding of the signalling processes mediated via these kinases with a particular focus on how these individual pathways converge to signalling networks that ultimately ensure the dynamic translation of extracellular nutrient signals into appropriate physiological responses.
@article{Smets2010Life,
abstract = {{Abstract\ \ Cells} of all living organisms contain complex signal transduction networks to ensure that a wide range of physiological properties are properly adapted to the environmental conditions. The fundamental concepts and individual building blocks of these signalling networks are generally well-conserved from yeast to man; yet, the central role that growth factors and hormones play in the regulation of signalling cascades in higher eukaryotes is executed by nutrients in yeast. Several nutrient-controlled pathways, which regulate cell growth and proliferation, metabolism and stress resistance, have been defined in yeast. These pathways are integrated into a signalling network, which ensures that yeast cells enter a quiescent, resting phase (G0) to survive periods of nutrient scarceness and that they rapidly resume growth and cell proliferation when nutrient conditions become favourable again. A series of well-conserved nutrient-sensory protein kinases perform key roles in this signalling network: i.e. Snf1, {PKA}, Tor1 and Tor2, Sch9 and {Pho85–Pho80}. In this review, we provide a comprehensive overview on the current understanding of the signalling processes mediated via these kinases with a particular focus on how these individual pathways converge to signalling networks that ultimately ensure the dynamic translation of extracellular nutrient signals into appropriate physiological responses.},
added-at = {2018-12-02T16:09:07.000+0100},
author = {Smets, Bart and Ghillebert, Ruben and De Snijder, Pepijn and Binda, Matteo and Swinnen, Erwin and De Virgilio, Claudio and Winderickx, Joris},
biburl = {https://www.bibsonomy.org/bibtex/2ffc4132635a147b850d313e8c734d0c1/karthikraman},
citeulike-article-id = {6505369},
citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00294-009-0287-1},
citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/20054690},
citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=20054690},
citeulike-linkout-3 = {http://www.springerlink.com/content/vg725l2627244422},
day = 1,
doi = {10.1007/s00294-009-0287-1},
interhash = {c1ffc8167ae7f88582ee0d547d3fb137},
intrahash = {ffc4132635a147b850d313e8c734d0c1},
issn = {0172-8083},
journal = {Current Genetics},
keywords = {signalling yeast},
month = feb,
number = 1,
pages = {1--32},
pmid = {20054690},
posted-at = {2010-01-08 16:13:02},
priority = {2},
timestamp = {2018-12-02T16:09:07.000+0100},
title = {Life in the midst of scarcity: adaptations to nutrient availability in Saccharomyces cerevisiae},
url = {http://dx.doi.org/10.1007/s00294-009-0287-1},
volume = 56,
year = 2010
}