%0 Journal Article %1 Bugaj2012Bringing %A Bugaj, Lukasz J. %A Schaffer, David V. %D 2012 %J Current opinion in chemical biology %K medicine synthetic-biology %R 10.1016/j.cbpa.2012.04.009 %T Bringing next-generation therapeutics to the clinic through synthetic biology. %U http://dx.doi.org/10.1016/j.cbpa.2012.04.009 %X Recent advances in synthetic biology have created genetic tools with the potential to enhance the specificity, dynamic control, efficacy, and safety of medical treatments. Interfacing these genetic devices with human patients may thus bring about more efficient treatments or entirely new solutions to presently intractable maladies. Here we review engineered circuits with clinical potential and discuss their design, implementation, and validation. Copyright \copyright 2012 Elsevier Ltd. All rights reserved.

@article{Bugaj2012Bringing, abstract = { Recent advances in synthetic biology have created genetic tools with the potential to enhance the specificity, dynamic control, efficacy, and safety of medical treatments. Interfacing these genetic devices with human patients may thus bring about more efficient treatments or entirely new solutions to presently intractable maladies. Here we review engineered circuits with clinical potential and discuss their design, implementation, and validation. Copyright {\copyright} 2012 Elsevier Ltd. All rights reserved. }, added-at = {2018-12-02T16:09:07.000+0100}, author = {Bugaj, Lukasz J. and Schaffer, David V.}, biburl = {https://www.bibsonomy.org/bibtex/233dec61d9559ebd1c6e6f157011f07e1/karthikraman}, citeulike-article-id = {10680368}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cbpa.2012.04.009}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/22609142}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=22609142}, day = 17, doi = {10.1016/j.cbpa.2012.04.009}, interhash = {300f4ff488db9ee83280073adbf75d8c}, intrahash = {33dec61d9559ebd1c6e6f157011f07e1}, issn = {1879-0402}, journal = {Current opinion in chemical biology}, keywords = {medicine synthetic-biology}, month = may, pmid = {22609142}, posted-at = {2012-05-24 05:36:21}, priority = {2}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Bringing next-generation therapeutics to the clinic through synthetic biology.}, url = {http://dx.doi.org/10.1016/j.cbpa.2012.04.009}, year = 2012 }