%0 Journal Article %1 Khoshoo1996 %A Khoshoo, V. %A Zembo, M. %A King, A. %A Dhar, M. %A Reifen, R. %A Pencharz, P. %D 1996 %J J Pediatr Gastroenterol Nutr %K Adolescent; Caseins; Cerebral Palsy; Child; Child, Preschool; Cross-Over Studies; Female; Food, Formulated; Gastroesophageal Reflux; Humans; Hydrogen-Ion Concentration; Male; Milk Proteins %N 1 %P 48--55 %T Incidence of gastroesophageal reflux with whey- and casein-based formulas in infants and in children with severe neurological impairment. %V 22 %X Ten exclusively gastrostomy-fed, neurologically impaired children (4.5-14.5 years old) with gastroesophageal reflux were randomly assigned to receive feedings with either a casein- or a whey-based formula for 48 h each and then crossed over to the other formula. One 24-h pH probe study each was performed while being fed casein- and whey-based formula, respectively. There was a significant reduction in episodes and duration of gastroesophageal reflux while consuming the whey-based formula (p < 0.05). Whey-based feedings should be considered an additional tool in conjunction with other antireflux measures to treat gastroesophageal reflux more effectively in children with severe neurological impairment. A similar study was also conducted involving 14 infants (3-12 months old) with documented gastroesophageal reflux using 24-h pH probe monitoring while consuming a casein-based formula. The formula was changed to a whey-based formula and the pH probe study repeated within 3-5 days. Four infants showed improvement and the rest showed either deterioration (1/14) or comparable results (9/14). The reduction in the mean number of episodes or duration of gastroesophageal reflux with the whey-formula was not significantly different from that with the casein-based formula (p > 0.05). Based on these findings, generalized recommendations for the use of whey-based formula in infants with gastroesophageal reflux cannot be made.

@article{Khoshoo1996, abstract = {Ten exclusively gastrostomy-fed, neurologically impaired children (4.5-14.5 years old) with gastroesophageal reflux were randomly assigned to receive feedings with either a casein- or a whey-based formula for 48 h each and then crossed over to the other formula. One 24-h pH probe study each was performed while being fed casein- and whey-based formula, respectively. There was a significant reduction in episodes and duration of gastroesophageal reflux while consuming the whey-based formula (p < 0.05). Whey-based feedings should be considered an additional tool in conjunction with other antireflux measures to treat gastroesophageal reflux more effectively in children with severe neurological impairment. A similar study was also conducted involving 14 infants (3-12 months old) with documented gastroesophageal reflux using 24-h pH probe monitoring while consuming a casein-based formula. The formula was changed to a whey-based formula and the pH probe study repeated within 3-5 days. Four infants showed improvement and the rest showed either deterioration (1/14) or comparable results (9/14). The reduction in the mean number of episodes or duration of gastroesophageal reflux with the whey-formula was not significantly different from that with the casein-based formula (p > 0.05). Based on these findings, generalized recommendations for the use of whey-based formula in infants with gastroesophageal reflux cannot be made.}, added-at = {2014-07-19T20:36:49.000+0200}, author = {Khoshoo, V. and Zembo, M. and King, A. and Dhar, M. and Reifen, R. and Pencharz, P.}, biburl = {https://www.bibsonomy.org/bibtex/24e04641b98886b85b62f11b5616eba16/ar0berts}, groups = {public}, interhash = {42588355c059c72c43eaceb394b834b8}, intrahash = {4e04641b98886b85b62f11b5616eba16}, journal = {J Pediatr Gastroenterol Nutr}, keywords = {Adolescent; Caseins; Cerebral Palsy; Child; Child, Preschool; Cross-Over Studies; Female; Food, Formulated; Gastroesophageal Reflux; Humans; Hydrogen-Ion Concentration; Male; Milk Proteins}, month = Jan, number = 1, pages = {48--55}, pmid = {8788287}, timestamp = {2014-07-19T20:36:49.000+0200}, title = {Incidence of gastroesophageal reflux with whey- and casein-based formulas in infants and in children with severe neurological impairment.}, username = {ar0berts}, volume = 22, year = 1996 }