%0 Journal Article %1 Hyduke2010Towards %A Hyduke, Daniel R. %A Palsson, Bernhard Ø. %D 2010 %I Nature Publishing Group %J Nature reviews. Genetics %K genome-scale reconstruction signalling %N 4 %P 297--307 %R 10.1038/nrg2750 %T Towards genome-scale signalling network reconstructions. %U http://dx.doi.org/10.1038/nrg2750 %V 11 %X Biological signalling networks allow living organisms to issue an integrated response to current conditions and make limited predictions about future environmental changes. Small-scale dynamic models of signalling cascades, including mitogen-activated protein kinase cascades, have been developed to generate hypotheses about signal transduction. Owing to technical limitations, these models and the hypotheses they generate have focused on a limited subset of signalling molecules. Now that we can simultaneously measure a substantial portion of the molecular components of a cell, we can begin to develop and test systems-level models of cellular signalling and regulatory processes, therefore gaining insights into the 'thought' processes of a cell.

@article{Hyduke2010Towards, abstract = {Biological signalling networks allow living organisms to issue an integrated response to current conditions and make limited predictions about future environmental changes. Small-scale dynamic models of signalling cascades, including mitogen-activated protein kinase cascades, have been developed to generate hypotheses about signal transduction. Owing to technical limitations, these models and the hypotheses they generate have focused on a limited subset of signalling molecules. Now that we can simultaneously measure a substantial portion of the molecular components of a cell, we can begin to develop and test systems-level models of cellular signalling and regulatory processes, therefore gaining insights into the 'thought' processes of a cell.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Hyduke, Daniel R. and Palsson, Bernhard {\O}.}, biburl = {https://www.bibsonomy.org/bibtex/2b07836905ede30b8e43df7c90be074c7/karthikraman}, citeulike-article-id = {6715247}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2750}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2750}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/20177425}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=20177425}, day = 23, doi = {10.1038/nrg2750}, interhash = {42f53b9871ca11e7212b6de40f1022bc}, intrahash = {b07836905ede30b8e43df7c90be074c7}, issn = {1471-0064}, journal = {Nature reviews. Genetics}, keywords = {genome-scale reconstruction signalling}, month = apr, number = 4, pages = {297--307}, pmid = {20177425}, posted-at = {2010-02-23 13:31:30}, priority = {2}, publisher = {Nature Publishing Group}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Towards genome-scale signalling network reconstructions.}, url = {http://dx.doi.org/10.1038/nrg2750}, volume = 11, year = 2010 }