Article,

394: The Analysis of Binary Responses from Toxicological Experiments Involving Reproduction and Teratogenicity

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Biometrics, 31 (4): pp. 949-952 (1975)

Abstract

This paper describes a parametric method for analyzing binary response data from completely randomized experiments in which the experimental units are animal litters. Responses within a litter are assumed to form a set of Bernoulli trials whose success probability varies between litters in the same treatment group according to a two parameter beta distribution. The parameters of the beta distribution for each treatment are estimated by maximum likelihood and treatment differences are tested by asymptotic likelihood ratio tests.

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