%0 Journal Article %1 an2018epidermal %A An, Zhenyi %A Aksoy, Ozlem %A Zheng, Tina %A Fan, Qi-Wen %A Weiss, William A. %D 2018 %J Oncogene %K EGFR EGFRvIII cancer-research fulltext %N 12 %P 1561--1575 %R 10.1038/s41388-017-0045-7 %T Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies %U https://doi.org/10.1038/s41388-017-0045-7 %V 37 %X Amplification of epidermal growth factor receptor (EGFR) and its active mutant EGFRvIII occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in pathogenesis, targeted therapy with EGFR-tyrosine kinase inhibitors (TKIs) or antibodies has only shown limited efficacy in patients. Here we discuss signaling pathways mediated by EGFR/EGFRvIII, current therapeutics, and novel strategies to target EGFR/EGFRvIII-amplified GBM.

@article{an2018epidermal, abstract = {Amplification of epidermal growth factor receptor (EGFR) and its active mutant EGFRvIII occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in pathogenesis, targeted therapy with EGFR-tyrosine kinase inhibitors (TKIs) or antibodies has only shown limited efficacy in patients. Here we discuss signaling pathways mediated by EGFR/EGFRvIII, current therapeutics, and novel strategies to target EGFR/EGFRvIII-amplified GBM.}, added-at = {2020-10-26T13:52:33.000+0100}, author = {An, Zhenyi and Aksoy, Ozlem and Zheng, Tina and Fan, Qi-Wen and Weiss, William A.}, biburl = {https://www.bibsonomy.org/bibtex/2c26bf67975cf9c7c7e21e4ab6b2cecdd/marcsaric}, description = {Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies | Oncogene}, doi = {10.1038/s41388-017-0045-7}, interhash = {5c275140e1fc0d7d360fe19ee9cc15d1}, intrahash = {c26bf67975cf9c7c7e21e4ab6b2cecdd}, issn = {14765594}, journal = {Oncogene}, keywords = {EGFR EGFRvIII cancer-research fulltext}, number = 12, pages = {1561--1575}, refid = {An2018}, timestamp = {2020-10-26T13:52:33.000+0100}, title = {Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies}, url = {https://doi.org/10.1038/s41388-017-0045-7}, volume = 37, year = 2018 }