%0 Journal Article %1 citeulike:892494 %A Ober, D. %A Hartmann, T. %C Institut für Pharmazeutische Biologie, Technische Universität Braunschweig, Germany. %D 2000 %J Plant Mol Biol %K natural-products n-oxidation biosynthesis %N 4 %P 445--450 %T Phylogenetic origin of a secondary pathway: the case of pyrrolizidine alkaloids. %U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11197320 %V 44 %X Recent studies have revealed high sequence similarity between homospermidine synthase (HSS), the first pathway-specific enzyme in the biosynthesis of pyrrolizidine alkaloids, a class of sporadically occurring plant defence compounds, and deoxyhypusine synthase (DHS), a ubiquitous enzyme involved in the post-translational activation of the eukaryotic initiation factor 5A (eIF5A). The recruitment of DHS during the evolution of the alkaloid pathway is discussed and interpreted as evolution by change of function.

@article{citeulike:892494, abstract = {Recent studies have revealed high sequence similarity between homospermidine synthase (HSS), the first pathway-specific enzyme in the biosynthesis of pyrrolizidine alkaloids, a class of sporadically occurring plant defence compounds, and deoxyhypusine synthase (DHS), a ubiquitous enzyme involved in the post-translational activation of the eukaryotic initiation factor 5A (eIF5A). The recruitment of DHS during the evolution of the alkaloid pathway is discussed and interpreted as evolution by change of function.}, added-at = {2006-10-23T11:08:30.000+0200}, address = {Institut für Pharmazeutische Biologie, Technische Universität Braunschweig, Germany.}, author = {Ober, D. and Hartmann, T.}, biburl = {https://www.bibsonomy.org/bibtex/21cee1e914e4a5ac1b5d229049c472154/robert}, citeulike-article-id = {892494}, interhash = {5d1c59decb33d5c42aa7fcd1183228ee}, intrahash = {1cee1e914e4a5ac1b5d229049c472154}, issn = {0167-4412}, journal = {Plant Mol Biol}, keywords = {natural-products n-oxidation biosynthesis}, month = {November}, number = 4, pages = {445--450}, priority = {2}, timestamp = {2006-10-23T11:08:30.000+0200}, title = {Phylogenetic origin of a secondary pathway: the case of pyrrolizidine alkaloids.}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve\&db=pubmed\&dopt=Abstract\&list_uids=11197320}, volume = 44, year = 2000 }