Abstract
The CellDrum provides an experimental setup to investigate the electromechanics of a cardiac tissue construct and particularly the effect of drugs. Experimental data were used to develop a respective computational electromechanical model. Until now, the experiments have been performed with a thin tissue construct. Mechanically, it was modeled as a materially and geometrically nonlinear shell. Future experiments with thicker tissue are planned. Thus, the mechanical model needs to be modified. This study aims to predict the outcome of such experiments using a nonlinear 3D continuum formulation. Here, the action of one drug, verapamil, was taken into account.
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