%0 Journal Article %1 soliman2016potential %A Soliman, Gamal A. %A Yusufoglu, Hasan %A Tatli-Çankaya, Irem %A Abdel-Rahman, Rehab F. %A Aarabaci Anul, Serap %A Akaydn, Galip %D 2016 %E JPPRes, %J Journal of Pharmacy & Pharmacognosy Research %K Achillea-nobilis Momordica-charantia anticonvulsant pentylenetetrazole seizures %N 3 %P 107-114 %T The potential anticonvulsant activity of the ethanolic extracts of Achillea nobilis and Momordica charantia in rats %U http://jppres.com/jppres/pdf/vol4/jppres16.110_4.3.107.pdf %V 4 %X Context: Currently available antiepileptic drugs have debilitating adverse effects. Natural products and plants already used in traditional medicine can be a good place to start in the search for safer and more effective options. Aims: To investigate the anticonvulsant potential of Achillea nobilis and Momordica charantia extracts in maximal electroshock (MES), as well as pentylenetetrazole (PTZ)- and strychnine nitrate (STN)- induced seizure models in rats. Methods: For each model, eight groups of 21-day-old male Albino rats were used. The 1st group was kept as control, 2nd as standard (diazepam, 7.5 mg/kg); 3rd – 5th treated with A. nobilis (100, 200 and 300 mg/kg); and 6th – 8th administered M. charantia (100, 200 and 300 mg/kg). After 30 min, rats were exposed to a shock of 150 mA by a convulsiometer, via ear electrodes for 2 s (in MES test) or sc injection of PTZ (85 mg/kg) or STN (2.5 mg/kg). Results: A. nobilis and M. charantia extracts (200 and 300 mg/kg) demonstrated dose-dependent anticonvulsant effect against MES-induced seizures. In the PTZ induced convulsion, A. nobilis and M. charantia (200 and 300 mg/kg) significantly slowed the commencement of convulsions and minimized the duration of seizures. A. nobilis (300 mg/kg) showed 60% protection in rats against STN induced seizures. In contrast, A. nobilis (100 and 200 mg/kg) and M. charantia (100, 200 and 300 mg/kg) showed no significant protection against STN-induced seizures in rats. Conclusions: The results of the present study suggest that both extracts exhibited marked anticonvulsant activities.

@article{soliman2016potential, abstract = {Context: Currently available antiepileptic drugs have debilitating adverse effects. Natural products and plants already used in traditional medicine can be a good place to start in the search for safer and more effective options. Aims: To investigate the anticonvulsant potential of Achillea nobilis and Momordica charantia extracts in maximal electroshock (MES), as well as pentylenetetrazole (PTZ)- and strychnine nitrate (STN)- induced seizure models in rats. Methods: For each model, eight groups of 21-day-old male Albino rats were used. The 1st group was kept as control, 2nd as standard (diazepam, 7.5 mg/kg); 3rd – 5th treated with A. nobilis (100, 200 and 300 mg/kg); and 6th – 8th administered M. charantia (100, 200 and 300 mg/kg). After 30 min, rats were exposed to a shock of 150 mA by a convulsiometer, via ear electrodes for 2 s (in MES test) or sc injection of PTZ (85 mg/kg) or STN (2.5 mg/kg). Results: A. nobilis and M. charantia extracts (200 and 300 mg/kg) demonstrated dose-dependent anticonvulsant effect against MES-induced seizures. In the PTZ induced convulsion, A. nobilis and M. charantia (200 and 300 mg/kg) significantly slowed the commencement of convulsions and minimized the duration of seizures. A. nobilis (300 mg/kg) showed 60% protection in rats against STN induced seizures. In contrast, A. nobilis (100 and 200 mg/kg) and M. charantia (100, 200 and 300 mg/kg) showed no significant protection against STN-induced seizures in rats. Conclusions: The results of the present study suggest that both extracts exhibited marked anticonvulsant activities.}, added-at = {2016-05-10T03:11:15.000+0200}, author = {Soliman, Gamal A. and Yusufoglu, Hasan and Tatli-Çankaya, Irem and Abdel-Rahman, Rehab F. and Aarabaci Anul, Serap and Akaydn, Galip}, biburl = {https://www.bibsonomy.org/bibtex/28bf91b6504f9c601d19ae786d5f4d23f/jppres}, editor = {JPPRes}, interhash = {603b7a5ddf87f715f8c4b6cc45ade935}, intrahash = {8bf91b6504f9c601d19ae786d5f4d23f}, journal = {Journal of Pharmacy & Pharmacognosy Research}, keywords = {Achillea-nobilis Momordica-charantia anticonvulsant pentylenetetrazole seizures}, month = jun, number = 3, pages = {107-114}, timestamp = {2016-05-10T03:11:15.000+0200}, title = {The potential anticonvulsant activity of the ethanolic extracts of Achillea nobilis and Momordica charantia in rats}, url = {http://jppres.com/jppres/pdf/vol4/jppres16.110_4.3.107.pdf}, volume = 4, year = 2016 }