Abstract
BACKGROUND: Estimation of renal function in patients with end-stage liver disease (ESLD) is complicated by several factors.
OBJECTIVE: To develop a practical and relatively inexpensive method for estimating creatinine production and clearance in patients with ESLD.
METHODS: Serum creatinine concentrations and urinary excretion of creatinine were measured in 27 patients with moderate-to-severe liver disease with the goal of developing equations to predict creatinine clearance from serum creatinine. Subjects were studied during an initial evaluation for a liver transplant program. Two 24 hour urine specimens were collected along with 3 serum samples over a 2 day evaluation period. Serum and urine creatinine concentrations were determined using both a modified Jaffe (autoanalyzer) method and an HPLC method. The data were analyzed using nonlinear mixed-effects modeling.
RESULTS: Considering both statistical criteria and physiological conventions through allometric scaling theory, creatinin
Users
Please
log in to take part in the discussion (add own reviews or comments).