%0 Journal Article %1 Sturm:2014:Nat-Rev-Cancer:24457416 %A Sturm, D %A Bender, S %A Jones, D T %A Lichter, P %A Grill, J %A Becher, O %A Hawkins, C %A Majewski, J %A Jones, C %A Costello, J F %A Iavarone, A %A Aldape, K %A Brennan, C W %A Jabado, N %A Pfister, S M %D 2014 %J Nat Rev Cancer %K ATRX cancer-research fulltext glioblastoma %N 2 %P 92-107 %R 10.1038/nrc3655 %T Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge %U https://www.ncbi.nlm.nih.gov/pubmed/24457416?dopt=Abstract %V 14 %X We have extended our understanding of the molecular biology that underlies adult glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents have remained a relatively under-investigated disease. The latest large-scale genomic and epigenomic profiling studies have yielded an unprecedented abundance of novel data and provided deeper insights into gliomagenesis across all age groups, which has highlighted key distinctions but also some commonalities. As we are on the verge of dissecting glioblastomas into meaningful biological subgroups, this Review summarizes the hallmark genetic alterations that are associated with distinct epigenetic features and patient characteristics in both paediatric and adult disease, and examines the complex interplay between the glioblastoma genome and epigenome.

@article{Sturm:2014:Nat-Rev-Cancer:24457416, abstract = {We have extended our understanding of the molecular biology that underlies adult glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents have remained a relatively under-investigated disease. The latest large-scale genomic and epigenomic profiling studies have yielded an unprecedented abundance of novel data and provided deeper insights into gliomagenesis across all age groups, which has highlighted key distinctions but also some commonalities. As we are on the verge of dissecting glioblastomas into meaningful biological subgroups, this Review summarizes the hallmark genetic alterations that are associated with distinct epigenetic features and patient characteristics in both paediatric and adult disease, and examines the complex interplay between the glioblastoma genome and epigenome.}, added-at = {2017-05-30T22:00:39.000+0200}, author = {Sturm, D and Bender, S and Jones, D T and Lichter, P and Grill, J and Becher, O and Hawkins, C and Majewski, J and Jones, C and Costello, J F and Iavarone, A and Aldape, K and Brennan, C W and Jabado, N and Pfister, S M}, biburl = {https://www.bibsonomy.org/bibtex/2c246b9c7acc035a5b28f4d6372532957/marcsaric}, description = {Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge. - PubMed - NCBI}, doi = {10.1038/nrc3655}, interhash = {67ab73e349db8ca891cb2dcb135056a4}, intrahash = {c246b9c7acc035a5b28f4d6372532957}, journal = {Nat Rev Cancer}, keywords = {ATRX cancer-research fulltext glioblastoma}, month = feb, number = 2, pages = {92-107}, pmid = {24457416}, timestamp = {2017-05-30T22:00:39.000+0200}, title = {Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge}, url = {https://www.ncbi.nlm.nih.gov/pubmed/24457416?dopt=Abstract}, volume = 14, year = 2014 }